Evaluation of Nephroprotective Efficacy of Hypoxic Preconditioning in Patients Undergoing Coronary Artery Bypass Surgery; Cardiorenal Medicine; Vol. 6, iss. 4
| Parent link: | Cardiorenal Medicine Vol. 6, iss. 4.— 2016.— [P. 328-336] |
|---|---|
| מחבר תאגידי: | |
| מחברים אחרים: | , , , |
| סיכום: | Title screen Background: Nonpulsatile blood flow plays an important role in the pathogenesis of renal dysfunction in patients with extracorporeal circulation. In our opinion, hypoxic preconditioning (HP) can be used to protect kidneys from postsurgical dysfunction. The aim of this study was to evaluate nephroprotective efficacy of HP in myocardial revascularization with extracorporeal circulation. Methods: The randomized, controlled trial was performed in 63 patients undergoing coronary artery bypass grafting (CABG). Thirty-three patients were subjected to HP during CABG; 30 patients were included in the comparison group. All patients underwent dynamic renal scintigraphy with 99mТc-diethylenetriaminepentaacetic acid and were subjected to measuring the concentration of lipocalin in blood serum before and after CABG. Results: After CABG, the mean values of the total glomerular filtration rate (GFR) and GFR for each kidney significantly decreased only in patients of the comparison group. Significant increases in the concentration of serum neutrophil gelatinase-associated lipocalin occurred 5 h after surgery both in the group with HP (70.65 ± 46.71 to 127.58 ± 98.46 ng/ml) and in the comparison group (65.01 ± 38.64 to 171.65 ± 89.91 ng/ml). At the same time, the mean difference values between pre- and postoperative lipocalin levels were 56.94 ± 51.75 ng/ml in the study group and 106.64 ± 51.27 ng/ml in the comparison group; these differences were highly statistically significant (р = 0.004). Conclusion: The results of our study showed that (i) HP exerts nephroprotection in patients undergoing on-pump CABG, and (ii) determination of the lipocalin-2 level can be used for early diagnosis of acute kidney injury in cardiac surgery patients. |
| שפה: | אנגלית |
| יצא לאור: |
2016
|
| נושאים: | |
| גישה מקוונת: | http://dx.doi.org/10.1159/000446571 |
| פורמט: | אלקטרוני Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=650568 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 650568 | ||
| 005 | 20250314110516.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\15786 | ||
| 090 | |a 650568 | ||
| 100 | |a 20161010d2016 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a JP | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Evaluation of Nephroprotective Efficacy of Hypoxic Preconditioning in Patients Undergoing Coronary Artery Bypass Surgery |f Zh. V. Vesnina [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 25 tit.] | ||
| 330 | |a Background: Nonpulsatile blood flow plays an important role in the pathogenesis of renal dysfunction in patients with extracorporeal circulation. In our opinion, hypoxic preconditioning (HP) can be used to protect kidneys from postsurgical dysfunction. The aim of this study was to evaluate nephroprotective efficacy of HP in myocardial revascularization with extracorporeal circulation. Methods: The randomized, controlled trial was performed in 63 patients undergoing coronary artery bypass grafting (CABG). Thirty-three patients were subjected to HP during CABG; 30 patients were included in the comparison group. All patients underwent dynamic renal scintigraphy with 99mТc-diethylenetriaminepentaacetic acid and were subjected to measuring the concentration of lipocalin in blood serum before and after CABG. Results: After CABG, the mean values of the total glomerular filtration rate (GFR) and GFR for each kidney significantly decreased only in patients of the comparison group. Significant increases in the concentration of serum neutrophil gelatinase-associated lipocalin occurred 5 h after surgery both in the group with HP (70.65 ± 46.71 to 127.58 ± 98.46 ng/ml) and in the comparison group (65.01 ± 38.64 to 171.65 ± 89.91 ng/ml). At the same time, the mean difference values between pre- and postoperative lipocalin levels were 56.94 ± 51.75 ng/ml in the study group and 106.64 ± 51.27 ng/ml in the comparison group; these differences were highly statistically significant (р = 0.004). Conclusion: The results of our study showed that (i) HP exerts nephroprotection in patients undergoing on-pump CABG, and (ii) determination of the lipocalin-2 level can be used for early diagnosis of acute kidney injury in cardiac surgery patients. | ||
| 461 | |t Cardiorenal Medicine | ||
| 463 | |t Vol. 6, iss. 4 |v [P. 328-336] |d 2016 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a аортокоронарное шунтирование | |
| 701 | 1 | |a Vesnina |b Zh. V. |c specialist in the field of medical technology |c laboratory assistant of Tomsk Polytechnic University, candidate of medical sciences |f 1962- |g Zhaneta Vladimirovna |3 (RuTPU)RU\TPU\pers\34255 |9 17786 | |
| 701 | 1 | |a Lishmanov |b Yu. B. |c specialist in the field of medical technology |c lead engineer aof Tomsk Polytechnic University, doctor of medical sciences |f 1951- |g Yury Borisovich |3 (RuTPU)RU\TPU\pers\34200 |9 17734 | |
| 701 | 1 | |a Nesterov |b E. A. |c Physicist, Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University |f 1976- |g Evgeny Alexandrovich |3 (RuTPU)RU\TPU\pers\32657 |9 16556 | |
| 701 | 1 | |a Aleksandrova |b Е. А. |g Ekaterina Aleksandrovna | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Физико-технический институт |b Лаборатория радиационного контроля № 31 |3 (RuTPU)RU\TPU\col\19161 |9 27383 |
| 801 | 2 | |a RU |b 63413507 |c 20161010 |g RCR | |
| 856 | 4 | |u http://dx.doi.org/10.1159/000446571 | |
| 942 | |c CF | ||