Intracellular redox induced drug release in cancerous and mesenchymal stem cells

Intracellular redox induced drug release in cancerous and mesenchymal stem cells

Bibliographic Details
Parent link:Colloids and Surfaces B: Biointerfaces: Scientific Journal
Vol. 147.— 2016.— [P. 450–458]
Corporate Author: Национальный исследовательский Томский политехнический университет Управление проректора по научной работе и инновациям Центр RASA в Томске Лаборатория новых лекарственных форм
Other Authors: Timin A. S. Aleksandr Sergeevich, Lepik K. V. Kirill, Muslimov A. M. Albert, Gorin D. A. Dmitry Aleksandrovich, Afanasyev B. Boris, Sukhorukov G. B. Gleb Borisovich
Summary:Title screen
In this report, we investigated intracellular redox induced drug release in cancerous cells and human mesenchymal stem cells (MSCs) as an example of healthy cells using redox-responsive microcapsules with covalently bonded anti-cancer drug (doxorubicin) via the amine-reactive cross-linker, 3,3′-dithiobis(sulfosuccinimidyl propionate) containing disulfide bond. Such rationally designed capsules with incorporated redox-sensitive cross-linker are capable of controllable Dox release in the presence of glutathione (GSH) due to a thiol-cleavable disulfide bonds. The treatment of human MSCs and human cervical cancer cell line (HeLa) with Dox-conjugated capsules showed that the Dox release was observed only when capsules incubated with HeLa cells which can be induced by high GSH level in cancerous (HeLa) cells. Moreover, the results of cell viability indicated that Dox-conjugated capsules are more effective when inducing cell death of HeLa than free Dox improving the anti-tumor efficacy of chemotherapeutic drug and simultaneously they possess lower cytotoxicity against MSCs compared to cancerous cells. Such properties are important in design of smart drug carriers for efficient cancer therapy.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1016/j.colsurfb.2016.08.034
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=650563

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