High-resolution synchrotron X-ray analysis of bioglass-enriched hydrogels

High-resolution synchrotron X-ray analysis of bioglass-enriched hydrogels

Библиографические подробности
Источник:Journal of Biomedical Materials Research - Part A: Scientific Journal.— , [s. a.]
Vol. 104, iss. 5.— 2016.— [P. 1194–1201]
Автор-организация: Национальный исследовательский Томский политехнический университет Физико-технический институт Кафедра теоретической и экспериментальной физики Центр технологий
Другие авторы: Gorodzha S. N. Svetlana Nikolaevna, Douglas T. E. L. Timothy, Samal S. K. Sangram, Detsch R. Rainer, Cholewa-Kowalska K. Katarzyna, Braeckmans K. Kevin, Boccaccini A. R. Aldo, Skirtach A. G. Andre, Weinhardt V. Venera, Baumbach T. Tilo, Surmenev R. A. Roman Anatolievich, Surmeneva M. A. Maria Alexandrovna
Примечания:Title screen
Enrichment of hydrogels with inorganic particles improves their suitability for bone regeneration by enhancing their mechanical properties, mineralizability, and bioactivity as well as adhesion, proliferation, and differentiation of bone-forming cells, while maintaining injectability. Low aggregation and homogeneous distribution maximize particle surface area, promoting mineralization, cell-particle interactions, and homogenous tissue regeneration. Hence, determination of the size and distribution of particles/particle agglomerates in the hydrogel is desirable. Commonly used techniques have drawbacks. High-resolution techniques (e.g., SEM) require drying. Distribution in the dry state is not representative of the wet state. Techniques in the wet state (histology, µCT) are of lower resolution. Here, self-gelling, injectable composites of Gellan Gum (GG) hydrogel and two different types of sol-gel-derived bioactive glass (bioglass) particles were analyzed in the wet state using Synchrotron X-ray radiation, enabling high-resolution determination of particle size and spatial distribution. The lower detection limit volume was 9 × 10−5 mm3. Bioglass particle suspensions were also studied using zeta potential measurements and Coulter analysis. Aggregation of bioglass particles in the GG hydrogels occurred and aggregate distribution was inhomogeneous. Bioglass promoted attachment of rat mesenchymal stem cells (rMSC) and mineralization.
Режим доступа: по договору с организацией-держателем ресурса
Язык:английский
Опубликовано: 2016
Предметы:
электронный ресурс
труды учёных ТПУ
Online-ссылка:http://dx.doi.org/10.1002/jbm.a.35642
Формат: Электронный ресурс Статья
Запись в KOHA:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=650554

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