The use of {99m}Tc-Al[2]O[3] for detection of sentinel lymph nodes in cervical cancer patients

The use of {99m}Tc-Al[2]O[3] for detection of sentinel lymph nodes in cervical cancer patients

Bibliographische Detailangaben
Parent link:IOP Conference Series: Materials Science and Engineering
Vol. 135 : Issues of Physics and Technology in Science, Industry and Medicine.— 2016.— [012043, 5 p.]
Körperschaft: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР)
Weitere Verfasser: Sinilkin I. G. Ivan Gennadjevich, Chernov V. I. Vladimir Ivanovich, Lyapunov A. Yu., Medvedeva А. А. Anna Aleksndrovna, Zelchan R. V. Roman Vladimirovich, Chernyshova A. L., Kolomiets L. A.
Zusammenfassung:Title screen
The purpose of the study was to evaluate the feasibility of using {99m}Tc-Al[2]O[3]- based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (TlaNxMx- T[2]bNxMx) treated at the Tomsk Cancer Research Institute. At 18 hours before surgery, 80 MBq of the {99m}Tc-Al[2]O[3] were injected peritumorally, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3(the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac, obturator, presacral and retrosacral regions (they amounted to 14%, respectively),and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.
Veröffentlicht: 2016
Schlagworte:
электронный ресурс
труды учёных ТПУ
лимфатические узлы
рак
радиофармпрепараты
компьютерная томография
Online-Zugang:http://dx.doi.org/10.1088/1757-899X/135/1/012043
http://earchive.tpu.ru/handle/11683/34833
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=650328

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