Magnetic silica hybrids modified with guanidine containing co-polymers for drug delivery applications; Materials Science and Engineering: C; Vol. 64

Magnetic silica hybrids modified with guanidine containing co-polymers for drug delivery applications; Materials Science and Engineering: C; Vol. 64

Bibliografiske detaljer
Parent link:Materials Science and Engineering: C.— , 1993-
Vol. 64.— 2016.— [P. 20–28]
Institution som forfatter: Национальный исследовательский Томский политехнический университет Управление проректора по научной работе и инновациям Центр RASA в Томске Лаборатория новых лекарственных форм
Andre forfattere: Timin A. S. Aleksandr Sergeevich, Kashirova S. Yu. Svetlana, Rumyantsev E. V. Evgeniy, Goncharenko A. A. Alexander
Summary:Title screen
Guanidine containing co-polymers grafted onto silica nanoparticles to form core-shell structure were prepared by sol-gel method in the presence of y-Fe2O3 nanoparticles. The morphological features for uncoated and coated silica particles have been characterized with scanning electron microscopy. The results show that the polymer coated silicas exhibit spherical morphology with rough polymeric surface covered by y-Fe2O3 nanoparticles. The grafting amount of guanidine containing co-polymers evaluated by thermogravimetric analysis was in the range from 17 to 30%. Then, the drug loading properties and cumulative release of silica hybrids modified with guanidine containing co-polymers were evaluated using molsidomine as a model drug. It was shown that after polymer grafting the loading content of molsidomine could reach up to 3.42 ± 0.21 and 2.34 ± 0.14 mg/g respectively. The maximum drug release of molsidomine is achieved at pH 1.6 (approximately 71–75% release at 37 °C), whereas at pH 7.4 drug release is lower (50.4–59.6% release at 37 °C). These results have an important implication that our magneto-controlled silica hybrids modified with guanidine containing co-polymers are promising as drug carriers with controlled behaviour under influence of magnetic field.
Режим доступа: по договору с организацией-держателем ресурса
Sprog:engelsk
Udgivet: 2016
Fag:
электронный ресурс
труды учёных ТПУ
silica core
polymer grafting
core-shell structure
drug carrier
magnetic properties
кремнозем
полимерные покрытия
полимерные поверхности
Online adgang:http://dx.doi.org/10.1016/j.msec.2016.03.057
Format: Electronisk Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=649753

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