Role of 5-HT2C receptors in dyskinesia; International Journal of Pharmacy and Pharmaceutical Sciences; Vol. 8, iss. 1

Role of 5-HT2C receptors in dyskinesia; International Journal of Pharmacy and Pharmaceutical Sciences; Vol. 8, iss. 1

Bibliographic Details
Parent link:International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 8, iss. 1.— 2016.— [P. 5-10]
Main Author: Loonen A. J. M. Anton
Corporate Author: Национальный исследовательский Томский политехнический университет Институт неразрушающего контроля Кафедра экологии и безопасности жизнедеятельности
Other Authors: Ivanova S. A. Svetlana Aleksandrovna
Summary:Title screen
By integrating knowledge gained by pharmacogenetic, neuroanatomical and pharmacological studies, a model can be constructed how serotonin (5-HT) affects the vulnerability to induce tardive dyskinesia. From neuroanatomical studies, it can be concluded that 5-HT inhibits the release ofdopamine (DA) within the dorsal striatum by affecting 5-HT2C receptors and also within the ventral striatum and prefrontal cortex by affecting 5-HT2A receptors. However, considering the low affinity of DA for its receptors, it is unlikely that the so released DA is able to displace atypicalantipsychotics from DA D2 and D3 receptors. 5-HT2C receptors and, to a lesser extent, 5-HT2A receptors, have constitutive activity and therefore,atypical antipsychotics can have inverse agonistic effects. It is hypothesized that decreasing the activity of 5-HT2 receptor carrying medium spinyneurons (MSNs) within the dorsal striatum represents the mechanism showing how atypical antipsychotics have limited ability to cause tardivedyskinesia.
Language:English
Published: 2016
Subjects:
труды учёных ТПУ
электронный ресурс
Online Access:http://innovareacademics.in/journals/index.php/ijpps/article/view/8736
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=649685

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