CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

Bibliographic Details
Parent link:Bulletin of Experimental Biology and Medicine: Scientific Journal
Vol. 160, iss. 5.— 2016.— [P. 718-721]
Corporate Author: Национальный исследовательский Томский политехнический университет Институт неразрушающего контроля Кафедра экологии и безопасности жизнедеятельности
Other Authors: Ivanova S. A. Svetlana Aleksandrovna, Filipenko M. L. Maksim Leonidovich, Vyalova N. M. Nataljya Mikhaylovna, Voronina E. N. Elena Nikolaevna, Pozhidaev I. Yu. Iljya Yurjevich, Osmanova D. I. Dilnaza Ilzatovna, Ivanova M. V. Margarita Viktorovna, Fedorenko O. Yu. Olga Yurievna, Semke A. V. Arkady Valentinovich, Bokhan N. A. Nikolay Aleksandrovich
Summary:Title screen
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1007/s10517-016-3250-4
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=649456
Description
Summary:Title screen
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1007/s10517-016-3250-4

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