Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors Central and Peripheral Types in the Cerebral Cortex of Heavy Drinkers Rats

Manylion Llyfryddiaeth
Parent link:	Journal of Alcoholism & Drug Dependence: Scientific Journal Vol. 4, iss. 2.— 2016.— [6 p.]
Awduron Corfforaethol:	Национальный исследовательский Томский политехнический университет Институт неразрушающего контроля Проблемная научно-исследовательская лаборатория электроники, диэлектриков и полупроводников, Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Кафедра биотехнологии и органической химии
Awduron Eraill:	Shushpanova T. V. Tamara Vladimirovna, Solonskii A. I. Anatoly Vladimirovich, Bokhan N. A. Nikolay Aleksandrovich, Novozheeva T. P. Tatjana Petrovna, Udut V. V. Vladimir Vasiljevich, Arbit G. A. Galina Aleksandrovna, Filimonov V. D. Viktor Dmitrievich
Crynodeb:	Title screen Objective: studies of anticonvulsants have a stimulating effect on neuronal receptors; in particular GABAA/ benzodiazepine receptor complex (GABAA/BzDR) can be the basis for the development of new approaches to the treatment of alcohol withdrawal syndrome (AWS) and alcohol addiction. Benzodiazepine receptors (BzDRs) of the cerebral cortex of Wistar male rats with a different preference for alcohol and BzDRs in the brain “heavy drinkers” rats, treated with original anticonvulsant meta-chloro-benzhydryl urea (m-ch-BHU) were examined in these study.Materials and methods: Wistar male rats (n=250) were used in an experimental model of alcoholism. Properties of the BzDRs of the “central” (synaptic) and “peripheral” (mitochondrial) type were examined in membrane fractions obtained from the cerebral cortex of rats under various experimental groups using radio receptor binding assays (RRA) selective ligands: [3H]flunitrazepam and [3H] Ro5-4864 to these receptors respectively.Results: our study has shown that the binding affinity of [3H] flunitrazepam and [3H] Ro5-4864 with synaptosomal and mitochondrial membranes was decreased, but capacity of receptors was increased in the cerebral cortex of rats prefer alcohol. Administration of m-ch-BHU increased affinity of BzDRs in the cortex of “heavy drinkers” rats that can enhance the mediation of GABA in the brain of these animals.Conclusion: Our data showed that m-ch-BHU has a stimulating effect on GABAA/BzDRs in the brains of “heavy drinkers” rats and may provide a new pharmacotherapeutic approach to the treatment of alcohol addiction. Режим доступа: по договору с организацией-держателем ресурса
Iaith:	Saesneg
Cyhoeddwyd:	2016
Pynciau:	электронный ресурс труды учёных ТПУ мочевина противосудорожные производные бензодиазепины головной мозг кора
Mynediad Ar-lein:	http://dx.doi.org/10.4172/2329-6488.1000234
Fformat:	Electronig Pennod Llyfr
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=649248