Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene

Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene

書誌詳細
Parent link:	Journal of Biosciences Vol. 407, iss. 5.— 2015.— [P. 873-883]
団体著者:	Национальный исследовательский Томский политехнический университет Физико-технический институт Кафедра прикладной физики (№ 12)
その他の著者:	Antontseva E. V. Elena Vyacheslavovna, Matveeva M. Yu. Marina Yurjevna, Bondar N. P. Natalia Petrovna, Kashina E. V. Elena Valentinovna, Leberfarb E. Yu. Elena Yurjevna, Bryzgalov L. O. Leonid Olegovich, Gervas P. A. Polina Anatolevna, Ponomareva A. A. Anastasiya Alekseevna, Cherdyntseva N. V. Nadezhda Viktorovna, Orlov Yu. L. Yury Lvovich, Merkulova T. I. Tatjyana Ivanovna
要約:	Title screen There are two regulatory single nucleotide polymorphisms (rSNPs) at the beginning of the second intron of the mouse K-ras gene that are strongly associated with lung cancer susceptibility. We performed functional analysis of three SNPs (rs12228277: T>A, rs12226937: G>A, and rs61761074: T>G) located in the same region of human KRAS. We found that rs12228277 and rs61761074 result in differential binding patterns of lung nuclear proteins to oligonucleotide probes corresponding two alternative alleles; in both cases, the transcription factor NF-Y is involved. G>A substitution (rs12226937) had no effect on the binding of lung nuclear proteins. However, all the nucleotide substitutions under study showed functional effects in a luciferase reporter assay. Among them, rs61761074 demonstrated a significant correlation with allele frequency in non-small-cell lung cancer (NSCLC). Taken together, the results of our study suggest that a T>G substitution at nucleotide position 615 in the second intron of the KRAS gene (rs61761074) may represent a promising genetic marker of NSCLC. Режим доступа: по договору с организацией-держателем ресурса
言語:	英語
出版事項:	2015
主題:	электронный ресурс труды учёных ТПУ
オンライン･アクセス:	http://dx.doi.org/10.1007/s12038-015-9567-8
フォーマット:	電子媒体図書の章
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=649028

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