Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene; Journal of Biosciences; Vol. 407, iss. 5

Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene; Journal of Biosciences; Vol. 407, iss. 5

Bibliographic Details
Parent link:Journal of Biosciences
Vol. 407, iss. 5.— 2015.— [P. 873-883]
Corporate Author: Национальный исследовательский Томский политехнический университет Физико-технический институт Кафедра прикладной физики (№ 12)
Other Authors: Antontseva E. V. Elena Vyacheslavovna, Matveeva M. Yu. Marina Yurjevna, Bondar N. P. Natalia Petrovna, Kashina E. V. Elena Valentinovna, Leberfarb E. Yu. Elena Yurjevna, Bryzgalov L. O. Leonid Olegovich, Gervas P. A. Polina Anatolevna, Ponomareva A. A. Anastasiya Alekseevna, Cherdyntseva N. V. Nadezhda Viktorovna, Orlov Yu. L. Yury Lvovich, Merkulova T. I. Tatjyana Ivanovna
Summary:Title screen
There are two regulatory single nucleotide polymorphisms (rSNPs) at the beginning of the second intron of the mouse K-ras gene that are strongly associated with lung cancer susceptibility. We performed functional analysis of three SNPs (rs12228277: T>A, rs12226937: G>A, and rs61761074: T>G) located in the same region of human KRAS. We found that rs12228277 and rs61761074 result in differential binding patterns of lung nuclear proteins to oligonucleotide probes corresponding two alternative alleles; in both cases, the transcription factor NF-Y is involved. G>A substitution (rs12226937) had no effect on the binding of lung nuclear proteins. However, all the nucleotide substitutions under study showed functional effects in a luciferase reporter assay. Among them, rs61761074 demonstrated a significant correlation with allele frequency in non-small-cell lung cancer (NSCLC). Taken together, the results of our study suggest that a T>G substitution at nucleotide position 615 in the second intron of the KRAS gene (rs61761074) may represent a promising genetic marker of NSCLC.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1007/s12038-015-9567-8
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=649028

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