Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium; Tumor Biology; Vol. 37, iss. 3

Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium; Tumor Biology; Vol. 37, iss. 3

Dettagli Bibliografici
Parent link:Tumor Biology: Scientific Journal.— , 1965-
Vol. 37, iss. 3.— 2016.— [P. 3599-3609]
Ente Autore: Национальный исследовательский Томский политехнический университет Физико-технический институт Кафедра прикладной физики (№ 12)
Altri autori: Pankova O. V. Olga Vladimirovna, Denisov E. V. Evgeny Vladimirovich, Ponomareva A. A. Anastasiya Alekseevna, Gerashchenko T. S. Tatiana Sergeevna, Tuzikov S. A. Sergey Alexandrovich, Perelmuter V. M. Vladimir Mikhaylovich
Riassunto:Title screen
Recurrences occur in 30 % of lung cancer patients after radical therapy; however, known prognostic factors are not always effective. In this study, we investigated whether the frequency of squamous non-small cell lung cancer (NSCLC) recurrence depends on the presence of reactive lesions in tumor-adjacent bronchial epithelium. Specimens of adjacent lung tissue from 104 patients with squamous NSCLC were used for the determination of basal cell hyperplasia (BCH) and squamous metaplasia (SM) and for the analysis of the expression of Ki-67, p53, Bcl-2, and CD138. We found that recurrence was observed in 36.7 % of patients with BCH combined with SM (BCH + SM+) in the same bronchus, compared with 1.8 % in patients with isolated BCH (BCH + SM?; odds ratio (OR) 31.26, 95 % confidence interval (CI) 3.77–258.60; p=?0.00002). The percentage of Ki-67-positive cells was significantly higher in BCH + SM+ than in BCH + SM? (34.9 vs. 18.3 %; effect size 2.86, 95 % CI 2.23–3.47; p?=?0.003). P53 expression was also more significant in BCH + SM+ than in BCH + SM? (14.4 vs. 9.6 %; effect size 1.22, 95 % CI 0.69–1.76; p=0.0008). In contrast, CD138 expression was lower in BCH + SM+ than in BCH + SM (21.8 vs. 38.5 %; effect size ?6.26, 95 % CI ?7.31 to ?5.22; p=?0.003). Based on our results, we concluded that the co-presence of reactive bronchial lesions is associated with the development of recurrent squamous NSCLC and may be a negative prognostic indicator. In addition, significant differences in Ki-67, p53, and CD138 expression exist between isolated BCH and BCH combined with SM that probably reflect part of biological differences, which could relate to the mechanism of lung cancer recurrence.
Режим доступа: по договору с организацией-держателем ресурса
Lingua:inglese
Pubblicazione: 2016
Soggetti:
электронный ресурс
труды учёных ТПУ
рекуррентность
рак легких
Accesso online:http://dx.doi.org/10.1007/s13277-015-4196-2
Natura: Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=648492

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