Experimental study of uptake of paramagnetic contrast agent Mn-rans-1,2-diaminocyclohexane-N,N,N`,N`-tetraacetate to brine tumors; Известия вузов. Физика; Т. 58, № 12-2
| Parent link: | Известия вузов. Физика: научный журнал.— , 1957- Т. 58, № 12-2.— 2016.— [С. 74-78] |
|---|---|
| निगमित लेखक: | |
| अन्य लेखक: | , , , , , |
| सारांश: | Заглавие с экрана Aim. We have evaluated the abilities of new original paramagnetic contrast agent Mn-DCTA (0.5 М solution of Manganese(II) complex with trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate, registered trade mark Cyclomang) for contrast-enhanced imaging of brain tumors in dogs. Material and Methods. Twelve animals were included, all with brain tumors revealed during out-patient veterinary examinations. In ten of twelve the diagnosis was verified later by pathomorphologic study. The cerebral MRI has been carried out as set of axial, sagittal and coronal slices as thin as three to five mm, covering all the volume of brain. The scanning parameters in T1-weighted spin-ech mode were as follows: TR = 400-600 ms, TE = 10-15 ms, the dose of injected paramagnetic was standardised as 1 mM per 10 kg of body weight. For quantitative analysis the index of enhancement was calculated as ratio : IE = (Intensity of T1-w MRIPost Mn-DCTA ) / (Intensity of T1-w MRI Pre Mn-DCTA ). Results. In all cases the sure enhancement with clear visualization of cerebral tumor was obtained due to highly intensive uptake of Mn-DCTA to the tumor tissue. When evaluated quantitatively the uptake of Mn-DCTA to the tumor gave the index of enhancement in T1-weighted spin-echo mode as high as IE = 1.67±0.23 for the central parts of tumor and IE = 2.08±0.22 for the peripheral ones.Intravenous injection of Mn-DCTA to dogs with cerebral tumors did not induce any detectable pathologic or even physiologic effects. Conclusions. The Mn-DCTA provides highly available methodologically simple imaging of cerebral tumors and can be thought out as promising paramagnetic agent for clinical magnetic resonance imaging. Режим доступа: по договору с организацией-держателем ресурса |
| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
2016
|
| विषय: | |
| ऑनलाइन पहुंच: | http://elibrary.ru/item.asp?id=25737833 |
| स्वरूप: | इलेक्ट्रोनिक पुस्तक अध्याय |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=648328 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 648328 | ||
| 005 | 20250220131744.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\13485 | ||
| 090 | |a 648328 | ||
| 100 | |a 20160517d2016 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a RU | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Experimental study of uptake of paramagnetic contrast agent Mn-rans-1,2-diaminocyclohexane-N,N,N`,N`-tetraacetate to brine tumors |f V. Yu. Usov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Заглавие с экрана | ||
| 320 | |a [References: p. 78 (13 tit.)] | ||
| 330 | |a Aim. We have evaluated the abilities of new original paramagnetic contrast agent Mn-DCTA (0.5 М solution of Manganese(II) complex with trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate, registered trade mark Cyclomang) for contrast-enhanced imaging of brain tumors in dogs. Material and Methods. Twelve animals were included, all with brain tumors revealed during out-patient veterinary examinations. In ten of twelve the diagnosis was verified later by pathomorphologic study. The cerebral MRI has been carried out as set of axial, sagittal and coronal slices as thin as three to five mm, covering all the volume of brain. The scanning parameters in T1-weighted spin-ech mode were as follows: TR = 400-600 ms, TE = 10-15 ms, the dose of injected paramagnetic was standardised as 1 mM per 10 kg of body weight. For quantitative analysis the index of enhancement was calculated as ratio : IE = (Intensity of T1-w MRIPost Mn-DCTA ) / (Intensity of T1-w MRI Pre Mn-DCTA ). Results. In all cases the sure enhancement with clear visualization of cerebral tumor was obtained due to highly intensive uptake of Mn-DCTA to the tumor tissue. When evaluated quantitatively the uptake of Mn-DCTA to the tumor gave the index of enhancement in T1-weighted spin-echo mode as high as IE = 1.67±0.23 for the central parts of tumor and IE = 2.08±0.22 for the peripheral ones.Intravenous injection of Mn-DCTA to dogs with cerebral tumors did not induce any detectable pathologic or even physiologic effects. Conclusions. The Mn-DCTA provides highly available methodologically simple imaging of cerebral tumors and can be thought out as promising paramagnetic agent for clinical magnetic resonance imaging. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Известия вузов. Физика |o научный журнал |d 1957- | ||
| 463 | |t Т. 58, № 12-2 |v [С. 74-78] |d 2016 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a магнитно-резонансная томография | |
| 610 | 1 | |a марганец | |
| 610 | 1 | |a парамагнитные соединения | |
| 701 | 1 | |a Usov |b V. Yu. |g Vladimir Yurjevich | |
| 701 | 1 | |a Bezlepkin |b A. I. |g Aleksandr Ivanovich | |
| 701 | 1 | |a Borodin |b O. Yu. |g Oleg Yurjevich | |
| 701 | 1 | |a Shimanovskiy |b N. L. |g Nikolay Lvovich | |
| 701 | 1 | |a Belyanin |b M. L. |c organic chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1973- |g Maksim L'vovich |3 (RuTPU)RU\TPU\pers\31268 |9 15446 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |3 (RuTPU)RU\TPU\pers\26423 |9 12127 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Институт физики высоких технологий |b Кафедра биотехнологии и органической химии |3 (RuTPU)RU\TPU\col\18693 |9 27146 |
| 801 | 2 | |a RU |b 63413507 |c 20160517 |g RCR | |
| 856 | 4 | |u http://elibrary.ru/item.asp?id=25737833 | |
| 942 | |c CF | ||