Influence of Antihypertensive Therapy on Cerebral Perfusion in Patients with Metabolic Syndrome: Relationship with Cognitive Function and 24-h Arterial Blood Pressure Monitoring; Cardiovascular Therapeutics; Vol. 33, iss. 4

Influence of Antihypertensive Therapy on Cerebral Perfusion in Patients with Metabolic Syndrome: Relationship with Cognitive Function and 24-h Arterial Blood Pressure Monitoring; Cardiovascular Therapeutics; Vol. 33, iss. 4

Bibliographic Details
Parent link:Cardiovascular Therapeutics
Vol. 33, iss. 4.— 2015.— [P. 209-215]
Corporate Author: Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория № 31 ядерного реактора
Other Authors: Efimova N. Yu. Nataliya Yurievna, Chernov V. I. Vladimir Ivanovich, Efimova I. Yu. Irina Yurjevna, Lishmanov Yu. B. Yury Borisovich
Summary:Title screen
AimsTo investigate the regional cerebral blood flow, cognitive function, and parameters of 24-h arterial blood pressure monitoring in patients with metabolic syndrome before and after combination antihypertensive therapy.MethodsThe study involved 54 patients with metabolic syndrome (MetS) investigated by brain single-photon emission computed tomography, 24-h blood pressure monitoring (ABPM), and comprehensive neuropsychological testing before and after 24 weeks of combination antihypertensive therapy.ResultsPatients with metabolic syndrome had significantly poorer regional cerebral blood flow compared with control group: by 7% (P = 0.003) in right anterior parietal cortex, by 6% (P = 0.028) in left anterior parietal cortex, by 8% (P = 0.007) in right superior frontal lobe, and by 10% (P = 0.00002) and 7% (P = 0.006) in right and left temporal brain regions, correspondingly. The results of neuropsychological testing showed 11% decrease in mentation (P = 0.002), and 19% (P = 0.011) and 20% (P = 0.009) decrease in immediate verbal and visual memory in patients with MetS as compared with control group. Relationships between the indices of ABPM, cerebral perfusion, and cognitive function were found. Data showed an improvement of regional cerebral blood flow, ABPM parameters, and indicators of cognitive functions after 6 months of antihypertensive therapy in patients with MetS.ConclusionThe study showed the presence of diffuse disturbances in cerebral perfusion is associated with cognitive disorders in patients with metabolic syndrome. Combination antihypertensive treatment exerts beneficial effects on the 24-h blood pressure profile, increases cerebral blood flow, and improves cognitive function in patients with MetS.
Language:English
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1111/1755-5922.12136
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647981

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