Opioids as Triggers of the Adaptive Phenomenon of Ischemic Preconditioning of the Heart; Neuroscience and Behavioral Physiology; Vol. 46, iss. 3
| Parent link: | Neuroscience and Behavioral Physiology.— , 1967- Vol. 46, iss. 3.— 2016.— [P. 319-327] |
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| Autor corporatiu: | |
| Altres autors: | , , , , , |
| Sumari: | Title screen Transient ischemia/reperfusion has been shown to evoke increases in enkephalin levels in myocardial tissue. Blockade of δ opioid receptors eliminates the cardioprotective effect of ischemic preconditioning both in vivo and in vitro. Inhibition of κ1 opioid receptors eliminates the cardioprotective effect of preconditioning only in vitro. Agonists of μ, δ1, δ2, and κ1 opioid receptors imitate the cardioprotective effect of preconditioning. These results indicate that endogenous opioid peptides are triggers of ischemic preconditioning. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | anglès |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | http://dx.doi.org/10.1007/s11055-016-0236-7 |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647811 |
| Sumari: | Title screen Transient ischemia/reperfusion has been shown to evoke increases in enkephalin levels in myocardial tissue. Blockade of δ opioid receptors eliminates the cardioprotective effect of ischemic preconditioning both in vivo and in vitro. Inhibition of κ1 opioid receptors eliminates the cardioprotective effect of preconditioning only in vitro. Agonists of μ, δ1, δ2, and κ1 opioid receptors imitate the cardioprotective effect of preconditioning. These results indicate that endogenous opioid peptides are triggers of ischemic preconditioning. Режим доступа: по договору с организацией-держателем ресурса |
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| DOI: | 10.1007/s11055-016-0236-7 |