Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions

Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions

Bibliographic Details
Parent link:Pharmaceutical Chemistry Journal
Vol. 49, iss. 4.— 2015.— [P. 250-253]
Corporate Author: Национальный исследовательский Томский политехнический университет Институт природных ресурсов Кафедра технологии органических веществ и полимерных материалов
Other Authors: Belousov M. V. Mikhail Valerievich, Akhmedzhanov R. R. Rafik Raviljevich, Zykova M. V., Vasil'ev K. Yu., Yusubov M. S. Mekhman Suleiman-Ogly (Suleimanovich)
Summary:Title screen
Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference antihypoxant dihydroquercetin in mouse brain and exceeded it in liver. The observed normalization by PHAs of oxidative phosphorylation in cerebral and hepatic mitochondria was probably related to their protective properties that prevented free-radical damage of cells and organelles under hypoxic conditions.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
humic acids
Peat humic acids (PHAs)
hypoxic
free-radical
гуминовые кислоты
Торф гуминовые кислоты (ПГА)
гипоксия
свободные радикалы
Online Access:http://dx.doi.org/10.1007/s11094-015-1265-1
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647650

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