Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions; Pharmaceutical Chemistry Journal; Vol. 49, iss. 4
| Parent link: | Pharmaceutical Chemistry Journal Vol. 49, iss. 4.— 2015.— [P. 250-253] |
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| Corporate Author: | |
| Other Authors: | , , , , |
| Summary: | Title screen Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference antihypoxant dihydroquercetin in mouse brain and exceeded it in liver. The observed normalization by PHAs of oxidative phosphorylation in cerebral and hepatic mitochondria was probably related to their protective properties that prevented free-radical damage of cells and organelles under hypoxic conditions. Режим доступа: по договору с организацией-держателем ресурса |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/s11094-015-1265-1 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647650 |
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| 200 | 1 | |a Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions |f M. V. Belousov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 27 tit.] | ||
| 330 | |a Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference antihypoxant dihydroquercetin in mouse brain and exceeded it in liver. The observed normalization by PHAs of oxidative phosphorylation in cerebral and hepatic mitochondria was probably related to their protective properties that prevented free-radical damage of cells and organelles under hypoxic conditions. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Pharmaceutical Chemistry Journal | ||
| 463 | |t Vol. 49, iss. 4 |v [P. 250-253] |d 2015 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a humic acids | |
| 610 | 1 | |a Peat humic acids (PHAs) | |
| 610 | 1 | |a hypoxic | |
| 610 | 1 | |a free-radical | |
| 610 | 1 | |a гуминовые кислоты | |
| 610 | 1 | |a Торф гуминовые кислоты (ПГА) | |
| 610 | 1 | |a гипоксия | |
| 610 | 1 | |a свободные радикалы | |
| 701 | 1 | |a Belousov |b M. V. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of Pharmaceutical Sciences |f 1963- |g Mikhail Valerievich |3 (RuTPU)RU\TPU\pers\45418 |9 21924 | |
| 701 | 1 | |a Akhmedzhanov |b R. R. |c specialist in the field of ecology and life safety |c Professor of Tomsk Polytechnic University, doctor of biological Sciences |f 1964- |g Rafik Raviljevich |3 (RuTPU)RU\TPU\pers\36886 |9 19915 | |
| 701 | 1 | |a Zykova |b M. V. | |
| 701 | 1 | |a Vasil'ev |b K. Yu. | |
| 701 | 1 | |a Yusubov |b M. S. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical sciences |f 1961- |g Mekhman Suleiman-Ogly (Suleimanovich) |3 (RuTPU)RU\TPU\pers\31833 |9 15928 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Институт природных ресурсов |b Кафедра технологии органических веществ и полимерных материалов |3 (RuTPU)RU\TPU\col\18659 |9 27112 |
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| 856 | 4 | |u http://dx.doi.org/10.1007/s11094-015-1265-1 | |
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