Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion

Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion

Bibliographic Details
Parent link:Bulletin of Experimental Biology and Medicine: Scientific Journal
Vol. 159, iss. 6.— 2015.— [P. 718-721]
Corporate Authors: Национальный исследовательский Томский политехнический университет Институт природных ресурсов Кафедра экономики природных ресурсов, Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория радиационного контроля № 31
Other Authors: Tsibulnikov S. Yu. Sergey Yurjevich, Maslov L. N. Leonid Nikolaevich, Mukhomedzyanov A. V. Aleksandr Valerjevich, Krylatov A. V. Andrey Vladimirovich, Tsibulnikova M. R. Margarita Radievna, Lishmanov Yu. B. Yury Borisovich
Summary:Title screen
We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1007/s10517-015-3057-8
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647538

Similar Items

Similar Items