Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion; Bulletin of Experimental Biology and Medicine; Vol. 159, iss. 6
| Parent link: | Bulletin of Experimental Biology and Medicine: Scientific Journal Vol. 159, iss. 6.— 2015.— [P. 718-721] |
|---|---|
| Співавтори: | , |
| Інші автори: | , , , , , |
| Резюме: | Title screen We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors. Режим доступа: по договору с организацией-держателем ресурса |
| Мова: | Англійська |
| Опубліковано: |
2015
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| Предмети: | |
| Онлайн доступ: | http://dx.doi.org/10.1007/s10517-015-3057-8 |
| Формат: | Електронний ресурс Частина з книги |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647538 |
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| 200 | 1 | |a Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion |f S. Yu. Tsibulnikov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 721 (8 tit.)] | ||
| 330 | |a We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Bulletin of Experimental Biology and Medicine |o Scientific Journal | ||
| 463 | |t Vol. 159, iss. 6 |v [P. 718-721] |d 2015 | ||
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| 701 | 1 | |a Tsibulnikov |b S. Yu. |c specialist in the field of medical technology |c Senior Lecturer of Tomsk Polytechnic University, Candidate of medical Sciences |f 1986- |g Sergey Yurjevich |3 (RuTPU)RU\TPU\pers\36547 |9 19595 | |
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| 701 | 1 | |a Mukhomedzyanov |b A. V. |g Aleksandr Valerjevich | |
| 701 | 1 | |a Krylatov |b A. V. |g Andrey Vladimirovich | |
| 701 | 1 | |a Tsibulnikova |b M. R. |c geologist |c Associate Professor of Tomsk Polytechnic University, Candidate of geographical sciences |f 1958- |g Margarita Radievna |3 (RuTPU)RU\TPU\pers\34019 |9 17586 | |
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