Fabrication, ultra-structure characterization and in vitro studies of RF magnetron sputter deposited nano-hydroxyapatite thin films for biomedical applications

Fabrication, ultra-structure characterization and in vitro studies of RF magnetron sputter deposited nano-hydroxyapatite thin films for biomedical applications

Bibliographic Details
Parent link:Applied Surface Science.— , 1984-
Vol. 317.— 2014.— [P. 172–180]
Corporate Authors: Национальный исследовательский Томский политехнический университет Физико-технический институт Кафедра теоретической и экспериментальной физики Центр технологий, Национальный исследовательский Томский политехнический университет Физико-технический институт Кафедра экспериментальной физики
Other Authors: Surmeneva M. A. Maria Alexandrovna, Surmenev R. A. Roman Anatolievich, Nikonova Y. A., Selezneva I. I., Ivanova A. A. Anna Aleksandrovna, Putlyaev A. A., Prymak O., Epple M.
Summary:Title screen
A series of nanostructured low-crystalline hydroxyapatite (HA) coatings averaging 170, 250, and 440 nm in thickness were deposited onto previously etched titanium substrates through radio-frequency (RF) magnetron sputtering. The HA coatings were analyzed using infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning and transmission electron microscopy (SEM and TEM). Cross sections of the thin specimens were prepared by FIB to study the microstructure of the coatings by TEM. The deposition process formed nano-scale grains, generating an amorphous layer at the substrate/coating interface and inducing the growth of a columnar grain structure perpendicular to the substrate surface. A microstructural analysis of the film confirmed that the grain size and crystallinity increased when increasing the deposition time. The nanostructured HA coatings were not cytotoxic, as proven by in vitro assays using primary dental pulp stem cells and mouse fibroblast NCTC clone L929 cells. Low-crystallinity HA coatings with different thicknesses stimulated cells to attach, proliferate and form mineralized nodules on the surface better than uncoated titanium substrates.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2014
Subjects:
электронный ресурс
труды учёных ТПУ
biomedical
thin-films
nano-hydroxyapatites
тонкие пленки
нано-гидроксиапатит
биомедицина
Online Access:http://dx.doi.org/10.1016/j.apsusc.2014.08.104
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=647477

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