Antioxidant and Immunotropic Properties of some Lithium Salts; Journal of Applied Pharmaceutical Science; Vol. 6 (1)

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Parent link:Journal of Applied Pharmaceutical Science
Vol. 6 (1).— 2016.— [P. 86-89]
Korporace: Национальный исследовательский Томский политехнический университет Институт природных ресурсов Кафедра физической и аналитической химии, Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Лаборатория № 12
Další autoři: Plotnikov E. V. Evgeny Vladimirovich, Voronova O. A. Olesya Aleksandrovna, Linert W. Wolfgang, Martemyanov D. V. Dmitry Vladimirovich, Korotkova E. I. Elena Ivanovna, Dorozhko E. V. Elena Vladimirovna, Astashkina A. P. Anna Pavlovna, Martemjyanova I. V. Irina Vladimirovna, Ivanova S. A. Svetlana Aleksandrovna, Bokhan N. A. Nikolay Aleksandrovich
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Objective: The antioxidant activity and immuno-tropic effects of lithium glutamate, lithium salicylate, lithium benzoate and lithium lactate have been investigated in this work, as a base for new psychotropic medicines. Methods: The antioxidant properties were studied by the voltammetric method. Phagocytic activity of neutrophilic leucocytes and the reaction of blastic transformation of lymphocytes were used as test for assessments of influence of the lithium compounds on the immune cells of human blood. Results: It was revealed absence of toxic action on human blood cells for all tested substances. Lithium benzoate showed the most significant stimulating influence on lymphocytes. Glutamate and benzoate lithium expressed scavenging activity vs oxygen radicals. Salicylate and benzoate lithium revealed significant phagocytosis stimulation effects. Conclusion: Investigated lithium salts expressed antioxidant activity and immunotropic effects, all investigated substance are of interest in medical application for mental diseases and comorbid pathology treatment.
Jazyk:angličtina
Vydáno: 2016
Témata:
On-line přístup:http://dx.doi.org/10.7324/JAPS.2016.600115
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=646827

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