A Molecular Dynamic Study of Layered Hydroxide Induced Depletion of Mobile Anions within the Extracellular Medium; AIP Conference Proceedings; Vol. 1683 : Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
| Parent link: | AIP Conference Proceedings Vol. 1683 : Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures.— 2015.— [020232, 4 p.] |
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| Zusammenfassung: | Title screen The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg[2]/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg[2]/Al-LDH nanosheets was determined. Режим доступа: по договору с организацией-держателем ресурса |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| Online-Zugang: | http://dx.doi.org/10.1063/1.4932922 |
| Format: | Elektronisch Buchkapitel |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=645030 |
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| 200 | 1 | |a A Molecular Dynamic Study of Layered Hydroxide Induced Depletion of Mobile Anions within the Extracellular Medium |f A. A. Tsukanov, S. G. Psakhie | |
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| 300 | |a Title screen | ||
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| 330 | |a The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg[2]/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg[2]/Al-LDH nanosheets was determined. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 | |0 (RuTPU)RU\TPU\network\4816 |t AIP Conference Proceedings | |
| 463 | 0 | |0 (RuTPU)RU\TPU\network\9779 |t Vol. 1683 : Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures |o Proceedings of the International Conference, 21–25 September 2015, Tomsk, Russia |f National Research Tomsk Polytechnic University (TPU) ; ed. V. E. Panin ; S. G. Psakhie ; V. M. Fomin |v [020232, 4 p.] |d 2015 | |
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| 610 | 1 | |a молекулярная динамика | |
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| 700 | 1 | |a Tsukanov |b A. A. |c physicist |c researcher of Tomsk Polytechnic University, candidate of physical and mathematical sciences |f 1984- |g Aleksey Alekseevich |2 stltpush |3 (RuTPU)RU\TPU\pers\35787 | |
| 701 | 1 | |a Psakhie |b S. G. |c physicist |c head of laboratory, Advisor to the rector, head of Department, Tomsk Polytechnic University, doctor of physico-mathematical Sciences |f 1952- |g Sergey Grigorievich |2 stltpush |3 (RuTPU)RU\TPU\pers\33038 | |
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