Hemozoin “knobs” in Opisthorchis felineus infected liver

Hemozoin “knobs” in Opisthorchis felineus infected liver

Dades bibliogràfiques
Parent link:Parasites & Vectors
Vol. 8.— 2015.— [459 [9 p.]
Autor corporatiu: Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ)
Altres autors: Pershina A. G. Aleksandra Gennadievna, Saltykova I. V. Irina Vladimirovna, Ivanov V. V. Vladimir Vladimirovich, Perina E. A. Ekaterina Aleksandrovna, Demin M. A., Shevelev O. B. Oleg Borisovich, Buzueva I. I. Irina Ivanovna, Gutakovsky A. K. Anton Konstantinovich, Vtorushin S. V. Sergey Vladimirovich, Ganebnykh I. N. Iljya Nikolaevich, Krasnov V. P. Vladimir Petrovich, Sazonov A. E. Aleksey Eduardovich, Ogorodova L. M. Lyudmila Mikhaylovna
Sumari:Title screen
Background Hemozoin is the pigment produced by some blood-feeding parasites. It demonstrates high diagnostic and therapeutic potential. In this work the formation of co-called hemozoin “knobs” - the bile duct ectasia filled up by hemozoin pigment - in Opisthorhis felineus infected hamster liver has been observed.Methods The O. felineus infected liver was examined by histological analysis and magnetic resonance imaging (MRI). The pigment hemozoin was identified by Fourier transform infrared spectroscopy and high resolution electrospray ionization mass spectrometry analysis. Hemozoin crystals were characterised by high resolution transmission electron microscopy.Results Hemozoin crystals produced by O. felineus have average length 403 nm and the length-to-width ratio equals 2.0. The regurgitation of hemozoin from parasitic fluke during infection leads to formation of bile duct ectasia. The active release of hemozoin from O. felineus during in vitroincubation has also been evidenced. It has been shown that the hemozoin knobs can be detected by magnetic resonance imaging.Conclusions In the paper for the first time the characterisation of hemozoin pigment extracted from liver fluke O. felineus has been conducted. The role of hemozoin in the modification of immune response by opisthorchiasis is assumed.
Режим доступа: по договору с организацией-держателем ресурса
Publicat: 2015
Matèries:
электронный ресурс
труды учёных ТПУ
hemozoin
trematode
Accés en línia:http://dx.doi.org/10.1186/s13071-015-1061-5
Format: Electrònic Capítol de llibre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=644062

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