Pharmacokinetic studies of new silver-based complex; International Journal of Pharmacy and Pharmaceutical Sciences; Vol. 7, iss. 6

Pharmacokinetic studies of new silver-based complex; International Journal of Pharmacy and Pharmaceutical Sciences; Vol. 7, iss. 6

Bibliographic Details
Parent link:International Journal of Pharmacy and Pharmaceutical Sciences: Scientific Journal.— , 2009-
Vol. 7, iss. 6.— 2015.— [P. 41-43]
Main Author: Silnikov V. A. Vladimir
Corporate Author: Национальный исследовательский Томский политехнический университет (ТПУ) Институт природных ресурсов (ИПР) Кафедра физической и аналитической химии (ФАХ)
Other Authors: Plotnikov E. V. Evgeny Vladimirovich, Plotnikov V. M. Vladimir Mikhaylovich
Summary:Title screen
Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.
Language:English
Published: 2015
Subjects:
труды учёных ТПУ
электронный ресурс
Online Access:http://innovareacademics.in/journals/index.php/ijpps/article/view/5396
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=643388

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