Pharmacokinetic studies of new silver-based complex; International Journal of Pharmacy and Pharmaceutical Sciences; Vol. 7, iss. 6
| Parent link: | International Journal of Pharmacy and Pharmaceutical Sciences: Scientific Journal.— , 2009- Vol. 7, iss. 6.— 2015.— [P. 41-43] |
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| Andre forfattere: | , |
| Summary: | Title screen Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment. |
| Sprog: | engelsk |
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2015
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| Online adgang: | http://innovareacademics.in/journals/index.php/ijpps/article/view/5396 |
| Format: | Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=643388 |
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| 200 | 1 | |a Pharmacokinetic studies of new silver-based complex |f V. A. Silnikov, E. V. Plotnikov, V. M. Plotnikov | |
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| 300 | |a Title screen | ||
| 320 | |a [References: p. 43 (6 tit.)] | ||
| 330 | |a Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment. | ||
| 461 | |t International Journal of Pharmacy and Pharmaceutical Sciences |o Scientific Journal |d 2009- | ||
| 463 | |t Vol. 7, iss. 6 |v [P. 41-43] |d 2015 | ||
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