Pharmacokinetic studies of new silver-based complex; International Journal of Pharmacy and Pharmaceutical Sciences; Vol. 7, iss. 6
| Parent link: | International Journal of Pharmacy and Pharmaceutical Sciences: Scientific Journal.— , 2009- Vol. 7, iss. 6.— 2015.— [P. 41-43] |
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| מחבר תאגידי: | |
| מחברים אחרים: | , |
| סיכום: | Title screen Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment. |
| שפה: | אנגלית |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | http://innovareacademics.in/journals/index.php/ijpps/article/view/5396 |
| פורמט: | אלקטרוני Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=643388 |
| סיכום: | Title screen Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment. |
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