Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis

Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis

Detaylı Bibliyografya
Parent link:Organic and Biomolecular Chemistry
Vol. 12, iss. 46.— 2015.— [P. 9350-9356]
Müşterek Yazar: Национальный исследовательский Томский политехнический университет (ТПУ) Институт природных ресурсов (ИПР) Кафедра технологии органических веществ и полимерных материалов (ТОВПМ)
Diğer Yazarlar: Velazquez V. H. Velazquez Heriberto, Garcia Ya. R. Yara Ruiz, Vandichel M. Matthias, Madder A. Annemieke, Verpoort F. V. K. Frensis Valter Kornelius
Özet:Title screen
Copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and terminal alkynes (CuAAC), better known as“click” reaction, has triggered the use of 1,2,3-triazoles in bioconjugation, drug discovery, materialsscience and combinatorial chemistry. Here we report a new series of water-soluble catalysts based onN-heterocyclic carbene (NHC)-Cu complexes which are additionally functionalized with a sulfonategroup. The complexes show superior activity towards CuAAC reactions and display a high versatility,enabling the production of triazoles with different substitution patterns. Additionally, successful applicationof these complexes in bioconjugation using unprotected peptides acting as DNA binding domainswas achieved for the first time. Mechanistic insight into the reaction mechanism is obtained by means ofstate-of-the-art first principles calculations.
Режим доступа: по договору с организацией-держателем ресурса
Baskı/Yayın Bilgisi: 2015
Konular:
электронный ресурс
труды учёных ТПУ
Online Erişim:http://dx.doi.org/10.1039/C4OB01350F
Materyal Türü: Elektronik Kitap Bölümü
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=643209

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