Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis; Organic and Biomolecular Chemistry; Vol. 12, iss. 46

Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis

Bibliographic Details
Parent link:Organic and Biomolecular Chemistry
Vol. 12, iss. 46.— 2015.— [P. 9350-9356]
Corporate Author: Национальный исследовательский Томский политехнический университет (ТПУ) Институт природных ресурсов (ИПР) Кафедра технологии органических веществ и полимерных материалов (ТОВПМ)
Other Authors: Velazquez V. H. Velazquez Heriberto, Garcia Ya. R. Yara Ruiz, Vandichel M. Matthias, Madder A. Annemieke, Verpoort F. V. K. Frensis Valter Kornelius
Summary:Title screen
Copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and terminal alkynes (CuAAC), better known as“click” reaction, has triggered the use of 1,2,3-triazoles in bioconjugation, drug discovery, materialsscience and combinatorial chemistry. Here we report a new series of water-soluble catalysts based onN-heterocyclic carbene (NHC)-Cu complexes which are additionally functionalized with a sulfonategroup. The complexes show superior activity towards CuAAC reactions and display a high versatility,enabling the production of triazoles with different substitution patterns. Additionally, successful applicationof these complexes in bioconjugation using unprotected peptides acting as DNA binding domainswas achieved for the first time. Mechanistic insight into the reaction mechanism is obtained by means ofstate-of-the-art first principles calculations.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1039/C4OB01350F
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=643209

Similar Items

Similar Items