Preclinical animal acute toxicity studies of new developed MRI contrast agent based on gadolinium

Preclinical animal acute toxicity studies of new developed MRI contrast agent based on gadolinium

Détails bibliographiques
Parent link:IOP Conference Series: Materials Science and Engineering
Vol. 81 : Radiation-Thermal Effects and Processes in Inorganic Materials.— 2015.— [012092, 5 p.]
Auteur principal: Nam I. F. Irina Feliksovna
Collectivité auteur: Национальный исследовательский Томский политехнический университет (ТПУ) Институт неразрушающего контроля (ИНК) Кафедра промышленной и медицинской электроники (ПМЭ)
Autres auteurs: Zhuk V. V.
Résumé:Title screen
Acute toxicity test of new developed MRI contrast agent based on disodium salt of gadopentetic acid complex were carried out on Mus musculus and Sprague Dawley rats according to guidelines of preclinical studies [1]. Groups of six animals each were selected for experiment. Death and clinical symptoms of animals were recorded during 14 days. As a result the maximum tolerated dose (MTD) for female mice is 2.8 mМ/kg of body weight, male mice - 1.4 mМ/kg, female rats - 2.8 mМ/kg, male rats - 5.6 mМ/kg of body weight. No Observed Adverse Effect Dose (NOAEL) for female mice is 1.4 mМ/kg, male mice - 0.7 mМ/kg, male and female rats - 0.7 mМ/kg. According to experimental data new developed MRI contrast agent based on Gd-DTPA complex is low-toxic.
Режим доступа: по договору с организацией-держателем ресурса
Langue:anglais
Publié: 2015
Sujets:
электронный ресурс
труды учёных ТПУ
токсичность
гадолиний
Accès en ligne:http://dx.doi.org/10.1088/1757-899X/81/1/012092
http://earchive.tpu.ru/handle/11683/14735
Format: Électronique Chapitre de livre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=643020

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