Nano-hydroxyapatite-coated metal-ceramic composite of iron-tricalcium phosphate: Improving the surface wettability, adhesion and proliferation of mesenchymal stem cells in vitro

Nano-hydroxyapatite-coated metal-ceramic composite of iron-tricalcium phosphate: Improving the surface wettability, adhesion and proliferation of mesenchymal stem cells in vitro

Podrobná bibliografie
Parent link:Colloids and Surfaces B: Biointerfaces: Scientific Journal
Vol. 135, iss. 1.— 2015.— [P. 386–393]
Korporativní autor: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра теоретической и экспериментальной физики (ТиЭФ) Центр технологий (ЦТ)
Další autoři: Surmeneva M. A. Maria Alexandrovna, Kleinhans C. Claudia, Vacun G. Gabriele, Kluger P. J. Petra Juliane, Schoenhaar V. Veronika, Mueller M. Michaela, Hein S. B. Sebastian Boris, Wittmar A. Alexandra, Ulbricht M. Mathias, Prymak O. Oleg, Oehr C. Christian, Surmenev R. A. Roman Anatolievich
Shrnutí:Title screen
Thin radio-frequency magnetron sputter deposited nano-hydroxyapatite (HA) films were prepared on the surface of a Fe-tricalcium phosphate (Fe-TCP) bioceramic composite, which was obtained using a conventional powder injection moulding technique. The obtained nano-hydroxyapatite coated Fe-TCP biocomposites (nano-HA-Fe-TCP) were studied with respect to their chemical and phase composition, surface morphology, water contact angle, surface free energy and hysteresis. The deposition process resulted in a homogeneous, single-phase HA coating. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells (hMSCs) was studied using biological short-term tests in vitro. The surface of the uncoated Fe-TCP bioceramic composite showed an initial cell attachment after 24 h of seeding, but adhesion, proliferation and growth did not persist during 14 days of culture. However, the HA-Fe-TCP surfaces allowed cell adhesion, and proliferation during 14 days. The deposition of the nano-HA films on the Fe-TCP surface resulted in higher surface energy, improved hydrophilicity and biocompatibility compared with the surface of the uncoated Fe-TCP. Furthermore, it is suggested that an increase in the polar component of the surface energy was responsible for the enhanced cell adhesion and proliferation in the case of the nano-HA-Fe-TCP biocomposites.
Режим доступа: по договору с организацией-держателем ресурса
Jazyk:angličtina
Vydáno: 2015
Témata:
электронный ресурс
труды учёных ТПУ
On-line přístup:http://dx.doi.org/10.1016/j.colsurfb.2015.07.057
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=642886

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