Artificial Niches for Stromal Stem Cells as a Potential Instrument for the Design of the Surface of Biomimetic Osteogenic Materials; Russian Physics Journal; Vol. 56, iss. 10

Artificial Niches for Stromal Stem Cells as a Potential Instrument for the Design of the Surface of Biomimetic Osteogenic Materials; Russian Physics Journal; Vol. 56, iss. 10

Bibliografiske detaljer
Parent link:Russian Physics Journal
Vol. 56, iss. 10.— 2014.— [P. 1206-1211]
Institution som forfatter: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра теоретической и экспериментальной физики (ТиЭФ)
Andre forfattere: Khlusov I. A. Igor Albertovich, Khlusova M. Yu., Pichugin V. F. Vladimir Fyodorovich, Sharkeev Yu. P. Yury Petrovich, Легостаева Е. В. Елена Викторовна
Summary:Title screen
A relationship between the topography of rough calcium phosphate surfaces having osteogenic niche-reliefs and the electrostatic potential of these surfaces as a possible instrument to control stromal stem cells has been investigated. The in vitro culture of human lung prenatal stromal cells on nanostructured/ultrafine-grained VT1.0 titanium alloy plates with bilateral rough calcium phosphate (CaP) microarc coating was used. It was established that the amplitude of the electret CaP surface potential linearly increased with increasing area of valleys (sockets), and the negative charge is formed on the socket surface. The area of alkaline phosphatase staining (the marker of osteoblast maturation and differentiation) of adherent CD34– CD44+ cells increases linearly with increasing area of artificial microterritory (socket) of the CaP surface occupied with each cell. The negative electret potential in valleys (sockets) of microarc CaP coatings can be the physical mechanism mediating the influence of the surface topography on osteogenic maturation and differentiation of cells in vitro. This mechanism can be called “niche-potential” and can be used as an instrument for biomimetic modification of smooth CaP surfaces to strengthen their integration with the bone tissue.
Режим доступа: по договору с организацией-держателем ресурса
Sprog:engelsk
Udgivet: 2014
Fag:
электронный ресурс
труды учёных ТПУ
Online adgang:http://elibrary.ru/item.asp?id=21864844
http://dx.doi.org/10.1007/s11182-014-0163-4
Format: Electronisk Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=642687

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