Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide; AIP Conference Proceedings; Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014
| Parent link: | AIP Conference Proceedings Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014.— 2014.— [P. 31-34] |
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| Korporace: | Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра физики высоких технологий в машиностроении (ФВТМ), Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра физики высоких технологий в машиностроении (ФВТМ) Сетевая научно-образовательная лаборатория "Динамическое моделирование и контроль ответственных конструкций" (НОЛ ММ) |
| Další autoři: | Bakina O. V. Olga Vladimirovna, Glazkova E. A. Elena Alekseevna, Svarovskaya N. V. Natalia Valentinovna, Lozhkomoev A. S. Aleksandr Sergeevich, Dygay A. М. Aleksandr, Churin A. A. Aleksey, Lerner M. I. Marat Izrailyevich, Psakhie S. G. Sergey Grigorievich |
| Shrnutí: | Title screen Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing. Режим доступа: по договору с организацией-держателем ресурса |
| Jazyk: | angličtina |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | http://dx.doi.org/10.1063/1.4901475 http://earchive.tpu.ru/handle/11683/35769 |
| Médium: | MixedMaterials Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=641958 |
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