A molecular dynamic study of charged nanofilm interaction with negative lipid bilayer; AIP Conference Proceedings; Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014

A molecular dynamic study of charged nanofilm interaction with negative lipid bilayer; AIP Conference Proceedings; Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014

Бібліографічні деталі
Parent link:	AIP Conference Proceedings Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014.— 2014.— [P. 639-642]
Автор:	Tsukanov A. A. Alexey
Співавтор:	Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра физики высоких технологий в машиностроении (ФВТМ)
Інші автори:	Psakhie S. G. Sergey Grigorievich
Резюме:	Title screen Hydrophobic and functionalized nanoparticles of different sizes and shapes have a various biomedical application, in particular anticancer therapy. It is known that charged nanoparticles may bind lipids and membrane proteins as well as cause lipid bilayer disruption. We have performed preliminary molecular dynamic simulations to investigate the effect of positively charged synthetic nanofilm, imitating a fragment of the two-dimensional folded AlOOH structure, on the POPE/POPG lipid membrane. It has been shown that the synthetic nanofilm with frozen coordinates tightens the membrane and binds lipid headgroups. Furthermore, the presence of the positively charged nanofilm perturbs the cation concentration in the near-surface membrane region. Режим доступа: по договору с организацией-держателем ресурса
Мова:	Англійська
Опубліковано:	2014
Предмети:	электронный ресурс труды учёных ТПУ молекулярно-динамические исследования нанопленки наночастицы терапия липидные мембраны биомедицинское применение
Онлайн доступ:	http://dx.doi.org/10.1063/1.4899026 http://earchive.tpu.ru/handle/11683/35762
Формат:	Електронний ресурс Частина з книги
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=641948

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