A molecular dynamic study of charged nanofilm interaction with negative lipid bilayer
| Parent link: | AIP Conference Proceedings Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014.— 2014.— [P. 639-642] |
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| 要約: | Title screen Hydrophobic and functionalized nanoparticles of different sizes and shapes have a various biomedical application, in particular anticancer therapy. It is known that charged nanoparticles may bind lipids and membrane proteins as well as cause lipid bilayer disruption. We have performed preliminary molecular dynamic simulations to investigate the effect of positively charged synthetic nanofilm, imitating a fragment of the two-dimensional folded AlOOH structure, on the POPE/POPG lipid membrane. It has been shown that the synthetic nanofilm with frozen coordinates tightens the membrane and binds lipid headgroups. Furthermore, the presence of the positively charged nanofilm perturbs the cation concentration in the near-surface membrane region. Режим доступа: по договору с организацией-держателем ресурса |
| 言語: | 英語 |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | http://dx.doi.org/10.1063/1.4899026 http://earchive.tpu.ru/handle/11683/35762 |
| フォーマット: | 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=641948 |
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| 200 | 1 | |a A molecular dynamic study of charged nanofilm interaction with negative lipid bilayer |f A. A. Tsukanov, S. G. Psakhie | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 642 (33 tit.)] | ||
| 330 | |a Hydrophobic and functionalized nanoparticles of different sizes and shapes have a various biomedical application, in particular anticancer therapy. It is known that charged nanoparticles may bind lipids and membrane proteins as well as cause lipid bilayer disruption. We have performed preliminary molecular dynamic simulations to investigate the effect of positively charged synthetic nanofilm, imitating a fragment of the two-dimensional folded AlOOH structure, on the POPE/POPG lipid membrane. It has been shown that the synthetic nanofilm with frozen coordinates tightens the membrane and binds lipid headgroups. Furthermore, the presence of the positively charged nanofilm perturbs the cation concentration in the near-surface membrane region. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 | |0 (RuTPU)RU\TPU\network\4816 |t AIP Conference Proceedings | |
| 463 | 0 | |0 (RuTPU)RU\TPU\network\4814 |t Vol. 1623 : International Conference on Physical Mesomechanics of Multilevel Systems 2014, Tomsk, Russia, 3–5 September 2014 |o [proceedings] |f National Research Tomsk Polytechnic University (TPU) |v [P. 639-642] |d 2014 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a молекулярно-динамические исследования | |
| 610 | 1 | |a нанопленки | |
| 610 | 1 | |a наночастицы | |
| 610 | 1 | |a терапия | |
| 610 | 1 | |a липидные мембраны | |
| 610 | 1 | |a биомедицинское применение | |
| 700 | 1 | |a Tsukanov |b A. A. |g Alexey | |
| 701 | 1 | |a Psakhie |b S. G. |c physicist |c head of laboratory, Advisor to the rector, head of Department, Tomsk Polytechnic University, doctor of physico-mathematical Sciences |f 1952- |g Sergey Grigorievich |2 stltpush |3 (RuTPU)RU\TPU\pers\33038 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет (ТПУ) |b Институт физики высоких технологий (ИФВТ) |b Кафедра физики высоких технологий в машиностроении (ФВТМ) |h 2087 |2 stltpush |3 (RuTPU)RU\TPU\col\18687 |
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| 856 | 4 | |u http://dx.doi.org/10.1063/1.4899026 | |
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/35762 | |
| 942 | |c CF | ||