Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility; The World Journal of Biological Psychiatry; Vol. 16, iss. 3

Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility; The World Journal of Biological Psychiatry; Vol. 16, iss. 3

Dettagli Bibliografici
Parent link:The World Journal of Biological Psychiatry
Vol. 16, iss. 3.— 2015.— [P. 200-205]
Ente Autore: Национальный исследовательский Томский политехнический университет (ТПУ) Институт неразрушающего контроля (ИНК) Кафедра экологии и безопасности жизнедеятельности (ЭБЖ)
Altri autori: Ivanova S. A. Svetlana Aleksandrovna, Toshchakova V. A. Valentina Aleksandrovna, Filipenko M. L. Maksim Leonidovich, Fedorenko O. Yu. Olga Yurievna, Boyarko E. G. Evgeniya Grigorjevna, Semke A. V. Arkady Valentinovich, Bokhan N. A. Nikolay Aleksandrovich, Aftanas L. V. Lyubomir Ivanovich, Lunen A. D. Anton DzhM
Riassunto:Title screen
Objectives. The aim of this study was to investigate a possible association between tardive dyskinesia (TD) and CYP1A2 (*1F, -163C>А, rs762551) polymorphism in Russian psychiatric inpatients. Methods. TD was assessed cross-sectionally using the Abnormal Involuntary Movement Scale (AIMS). Orofacial and limb-truncal dyskinesia were assessed with AIMS 1–4 and 5–7, respectively. Standard protocols were applied for genotyping. Analysis of covariance (ANCOVA) was used to compare the mean AIMS scores for each of the genotypic classes. Results. A total of 319 Caucasian patients from West Siberia with schizophrenia and 117 healthy volunteers were investigated. No significant differences between the patients and the controls in genotype frequencies were found. Analysis of covariance (ANCOVA) with age, sex, duration of disease, chlorpromazine equivalent (CPZEQ) incorporated as covariates showed that limb-truncal, but not orofacial TD, is associated with CYP1A2 (?163C>, rs762551) polymorphism (F = 3.27, P = 0.039). Patients with the C/C genotype had a higher mean AIMS 5–7 score than those with the A/C or the A/A genotype. Conclusions. Our results support the hypothesis that not only with clozapine, but also with other classical and atypical antipsychotics, smoking may decrease plasma levels; this is most extensively expressed in carriers of the CYP1A2*1F (-163C> A) polymorphism.
Режим доступа: по договору с организацией-держателем ресурса
Lingua:inglese
Pubblicazione: 2015
Soggetti:
электронный ресурс
труды учёных ТПУ
Accesso online:http://dx.doi.org/10.3109/15622975.2014.995222
Natura: MixedMaterials Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=640158

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