Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2'-bipyridyl mixed ligand copper(II) complexes

Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2'-bipyridyl mixed ligand copper(II) complexes

Dades bibliogràfiques
Parent link:	Dalton Transactions: The international journal for inorganic, organometallic and bioinorganic chemistry № 23.— 2009.— [P. 4488-4498]
Altres autors:	Potapov A. S. Andrey Sergeevich, Nudnova E. A., Domina G. A., Kirpotina L. N., Quinn M. T., Khlebnikov A. I. Andrey Ivanovich, Shchepyotkin I. A. Igor Aleksandrovich
Sumari:	Title screen Eleven new complexes of Cu(II) chloride and nitrate with bis(pyrazol-1-yl)propane and bis[2-(pyrazol-1-yl)ethyl]ether ligands were prepared and characterized by spectral and electrochemical methods. X-Ray crystal structure determination of bis[2-(3,5-dimethylpyrazol-1-yl)ethyl]etherdinitratocopper revealed a hepta-coordinated structure with the bis(pyrazole) ligand coordinated in a tridentate NNO-fashion and both of the nitrate ions in a bidentate fashion. Reaction of Cu(II) nitrate complexes with 2,2'-bipyridyl led to the displacement of one of the nitrate ions into the outer sphere and the formation of mixed-ligand complexes. Mixed-ligand bipyridyl Cu(II) complexes demonstrated the highest superoxide dismutase (SOD)-like activity in a chemical superoxide anion-generating system, with IC50 values in the low micromolar range. Density functional theory calculations showed that introduction of a bipypidyl ligand into the complexes dramatically lowered the lowest unoccupied molecular orbital (LUMO) energy level, which explains the increased SOD-like activity of these complexes compared to non-bipy species. These bipy complexes were also effective scavengers of reactive oxygen species generated by phagocytes (human neutrophils and murine bone marrow leukocytes) ex vivo. Thus, these bipy mixed-ligand complexes represent a promising class of SOD mimetics for future development. Режим доступа: по договору с организацией-держателем ресурса
Idioma:	anglès
Publicat:	2009
Matèries:	электронный ресурс труды учёных ТПУ
Accés en línia:	http://dx.doi.org/10.1039/B900869A
Format:	Electrònic Capítol de llibre
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=639616

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