Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2'-bipyridyl mixed ligand copper(II) complexes; Dalton Transactions; № 23
| Parent link: | Dalton Transactions: The international journal for inorganic, organometallic and bioinorganic chemistry № 23.— 2009.— [P. 4488-4498] |
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| Awduron Eraill: | , , , , , , |
| Crynodeb: | Title screen Eleven new complexes of Cu(II) chloride and nitrate with bis(pyrazol-1-yl)propane and bis[2-(pyrazol-1-yl)ethyl]ether ligands were prepared and characterized by spectral and electrochemical methods. X-Ray crystal structure determination of bis[2-(3,5-dimethylpyrazol-1-yl)ethyl]etherdinitratocopper revealed a hepta-coordinated structure with the bis(pyrazole) ligand coordinated in a tridentate NNO-fashion and both of the nitrate ions in a bidentate fashion. Reaction of Cu(II) nitrate complexes with 2,2'-bipyridyl led to the displacement of one of the nitrate ions into the outer sphere and the formation of mixed-ligand complexes. Mixed-ligand bipyridyl Cu(II) complexes demonstrated the highest superoxide dismutase (SOD)-like activity in a chemical superoxide anion-generating system, with IC50 values in the low micromolar range. Density functional theory calculations showed that introduction of a bipypidyl ligand into the complexes dramatically lowered the lowest unoccupied molecular orbital (LUMO) energy level, which explains the increased SOD-like activity of these complexes compared to non-bipy species. These bipy complexes were also effective scavengers of reactive oxygen species generated by phagocytes (human neutrophils and murine bone marrow leukocytes) ex vivo. Thus, these bipy mixed-ligand complexes represent a promising class of SOD mimetics for future development. Режим доступа: по договору с организацией-держателем ресурса |
| Iaith: | Saesneg |
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2009
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| Mynediad Ar-lein: | http://dx.doi.org/10.1039/B900869A |
| Fformat: | Electronig Pennod Llyfr |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=639616 |
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| 200 | 1 | |a Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2'-bipyridyl mixed ligand copper(II) complexes |f A. S. Potapov, E. A. Nudnova, G. A. Domina [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 4498 (66 tit.)] | ||
| 330 | |a Eleven new complexes of Cu(II) chloride and nitrate with bis(pyrazol-1-yl)propane and bis[2-(pyrazol-1-yl)ethyl]ether ligands were prepared and characterized by spectral and electrochemical methods. X-Ray crystal structure determination of bis[2-(3,5-dimethylpyrazol-1-yl)ethyl]etherdinitratocopper revealed a hepta-coordinated structure with the bis(pyrazole) ligand coordinated in a tridentate NNO-fashion and both of the nitrate ions in a bidentate fashion. Reaction of Cu(II) nitrate complexes with 2,2'-bipyridyl led to the displacement of one of the nitrate ions into the outer sphere and the formation of mixed-ligand complexes. Mixed-ligand bipyridyl Cu(II) complexes demonstrated the highest superoxide dismutase (SOD)-like activity in a chemical superoxide anion-generating system, with IC50 values in the low micromolar range. Density functional theory calculations showed that introduction of a bipypidyl ligand into the complexes dramatically lowered the lowest unoccupied molecular orbital (LUMO) energy level, which explains the increased SOD-like activity of these complexes compared to non-bipy species. These bipy complexes were also effective scavengers of reactive oxygen species generated by phagocytes (human neutrophils and murine bone marrow leukocytes) ex vivo. Thus, these bipy mixed-ligand complexes represent a promising class of SOD mimetics for future development. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Dalton Transactions |o The international journal for inorganic, organometallic and bioinorganic chemistry | ||
| 463 | |t № 23 |v [P. 4488-4498] |d 2009 | ||
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| 701 | 1 | |a Potapov |b A. S. |c Chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical sciences |f 1981- |g Andrey Sergeevich |3 (RuTPU)RU\TPU\pers\33909 |9 17482 | |
| 701 | 1 | |a Nudnova |b E. A. | |
| 701 | 1 | |a Domina |b G. A. | |
| 701 | 1 | |a Kirpotina |b L. N. | |
| 701 | 1 | |a Quinn |b M. T. | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |3 (RuTPU)RU\TPU\pers\33927 |9 17500 | |
| 701 | 1 | |a Shchepyotkin |b I. A. |c doctor-biophysicist |c leading researcher of Tomsk Polytechnic University, candidate of medical science |f 1962- |g Igor Aleksandrovich |3 (RuTPU)RU\TPU\pers\37358 | |
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| 856 | 4 | |u http://dx.doi.org/10.1039/B900869A | |
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