Facile Synthesis of Flexible Bis(pyrazol-1-yl)alkane and Related Ligands in a Superbasic Medium

Facile Synthesis of Flexible Bis(pyrazol-1-yl)alkane and Related Ligands in a Superbasic Medium

Bibliographic Details
Parent link:	European Journal of Organic Chemistry: Scientific Journal Vol. 2007, iss. 30.— 2007.— [P. 5112–5116]
Other Authors:	Potapov A. S. Andrey Sergeevich, Domina G. A., Khlebnikov A. I. Andrey Ivanovich, Ogorodnikov V. D.
Summary:	Title screen Flexible ligands 1,3-bis(pyrazol-1-yl)propanes, bis[2-(pyrazol-1-yl)ethyl] ethers, and bis[2-(3,5-dimethylpyrazol-1-yl)ethyl]amine were prepared by a facile procedure involving the reaction of pyrazoles with 1,3-dibromopropane, bis(2-chloroethyl) ether or bis(2-chloroethyl)amine hydrochloride in a superbasic medium (dimethyl sulfoxide/potassium hydroxide). Reaction of bis(2-chloroethyl)amine and pyrazole unexpectedly led to 1,4-bis[2-(pyrazol-1-yl)ethyl]piperazine. The corresponding 4,4?-diiodo-substituted bis(pyrazole) derivatives were prepared by oxidative iodination with I2/HIO3/H2SO4 in acetic acid. Vilsmeier–Haak formylation of some of the prepared compounds yielded the corresponding dialdehydes.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Language:	English
Published:	2007
Subjects:	электронный ресурс труды учёных ТПУ Pyrazole derivatives Superbasic systems Chelating ligands Iodination Flexible ligands
Online Access:	http://dx.doi.org/10.1002/ejoc.200700353
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=639608

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