Decomposition of reactive oxygen species by copper(II) bis(1-pyrazolyl)methane complexes; Journal of Biological Inorganic Chemistry; Vol. 11, iss. 4

Decomposition of reactive oxygen species by copper(II) bis(1-pyrazolyl)methane complexes; Journal of Biological Inorganic Chemistry; Vol. 11, iss. 4

Détails bibliographiques
Parent link:Journal of Biological Inorganic Chemistry
Vol. 11, iss. 4.— 2006.— [P. 499-513]
Autres auteurs: Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Potapov A. S. Andrey Sergeevich, Khlebnikov A. I. Andrey Ivanovich, Korotkova E. I. Elena Ivanovna, Lukina A., Malovichko G., Kirpotina L., Quinn M. T.
Résumé:Title screen
Two bis(1-pyrazolyl)alkane ligands, bis(3,5-dimethyl-1-pyrazolyl)methane and bis(4-iodo-3,5-dimethyl-1-pyrazolyl)methane, and their copper(II) complexes, bis(3,5-dimethyl-1-pyrazolyl)methanedinitratocopper(II) [CuL1(NO3)2] and bis(4-iodo-3,5-dimethyl-1-pyrazolyl)methanedinitratocopper(II) [CuL2(NO3)2]·2H2O, were prepared. Physiochemical properties of the copper(II) complexes were studied by spectroscopic (UV–vis, IR, EPR) techniques and cyclic voltammetry. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:copper(II) ion and a bindentate coordination mode for the nitrate ions in both of the complexes. According to experimental and theoretical ab initio data, the copper(II) ion is located in an octahedral hexacoordinated environment. Both complexes were able to catalyze the dismutation of superoxide anion ( O2) (pH 7.5) and decomposition of H2O2 (pH 7.5) and peroxynitrite (pH 10.9). In addition, both complexes exhibited superoxide dismutase (SOD) like activity toward extracellular and intracellular reactive oxygen species produced by activated human neutrophils in whole blood. Thus, these complexes represent useful SOD mimetics with a broad range of antioxidant activity toward a variety of reactive oxidants.
Режим доступа: по договору с организацией-держателем ресурса
Langue:anglais
Publié: 2006
Sujets:
электронный ресурс
труды учёных ТПУ
Accès en ligne:http://dx.doi.org/10.1007/s00775-006-0101-1
Format: Électronique Chapitre de livre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=639597

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