Exercise and NO production: relevance and implications inthe cardiopulmonary system

Exercise and NO production: relevance and implications inthe cardiopulmonary system

Bibliographic Details
Parent link:Frontiers in Cell and Developmental Biology
Vol. 2.— 2014.— [P. 73]
Other Authors: Nosarev A. V. Aleksey Valerievich, Smagliy L. V., Anfinogenova Ya. J. Yana Jonovna, Popov S. V., Kapilevich L. V. Leonid Vladimirovich
Summary:Title screen
This article reviews the existing knowledge about the effects of physical exercise on nitric oxide (NO) production in the cardiopulmonary system. The authors review the sources of NO in the cardiopulmonary system; involvement of three forms of NO synthases (eNOS, nNOS, and iNOS) in exercise physiology; exercise-induced modulation of NO and/or NOS in physiological and pathophysiological conditions in human subjects and animal models in the absence and presence of pharmacological modulators; and significance of exercise-induced NO production in health and disease. The authors suggest that physical activity significantly improves functioning of the cardiovascular system through an increase in NO bioavailability, potentiation of antioxidant defense, and decrease in the expression of reactive oxygen species-forming enzymes. Regular physical exercises are considered a useful approach to treat cardiovascular diseases. Future studies should focus on detailed identification of (i) the exercise-mediated mechanisms of NO exchange; (ii) optimal exercise approaches to improve cardiovascular function in health and disease; and (iii) physical effort thresholds.
Published: 2014
Subjects:
электронный ресурс
труды учёных ТПУ
nitric oxide
nitric oxide synthase
exercise
cardiopulmonary system
blood vessels
Online Access:http://dx.doi.org/10.3389%2Ffcell.2014.00073
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=638983

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