Exercise and NO production: relevance and implications inthe cardiopulmonary system; Frontiers in Cell and Developmental Biology; Vol. 2
| Parent link: | Frontiers in Cell and Developmental Biology Vol. 2.— 2014.— [P. 73] |
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| מחברים אחרים: | , , , , |
| סיכום: | Title screen This article reviews the existing knowledge about the effects of physical exercise on nitric oxide (NO) production in the cardiopulmonary system. The authors review the sources of NO in the cardiopulmonary system; involvement of three forms of NO synthases (eNOS, nNOS, and iNOS) in exercise physiology; exercise-induced modulation of NO and/or NOS in physiological and pathophysiological conditions in human subjects and animal models in the absence and presence of pharmacological modulators; and significance of exercise-induced NO production in health and disease. The authors suggest that physical activity significantly improves functioning of the cardiovascular system through an increase in NO bioavailability, potentiation of antioxidant defense, and decrease in the expression of reactive oxygen species-forming enzymes. Regular physical exercises are considered a useful approach to treat cardiovascular diseases. Future studies should focus on detailed identification of (i) the exercise-mediated mechanisms of NO exchange; (ii) optimal exercise approaches to improve cardiovascular function in health and disease; and (iii) physical effort thresholds. |
| שפה: | אנגלית |
| יצא לאור: |
2014
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| נושאים: | |
| גישה מקוונת: | http://dx.doi.org/10.3389%2Ffcell.2014.00073 |
| פורמט: | xMaterials אלקטרוני Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=638983 |
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| 200 | 1 | |a Exercise and NO production: relevance and implications inthe cardiopulmonary system |f A. V. Nosarev [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 131 tit.] | ||
| 330 | |a This article reviews the existing knowledge about the effects of physical exercise on nitric oxide (NO) production in the cardiopulmonary system. The authors review the sources of NO in the cardiopulmonary system; involvement of three forms of NO synthases (eNOS, nNOS, and iNOS) in exercise physiology; exercise-induced modulation of NO and/or NOS in physiological and pathophysiological conditions in human subjects and animal models in the absence and presence of pharmacological modulators; and significance of exercise-induced NO production in health and disease. The authors suggest that physical activity significantly improves functioning of the cardiovascular system through an increase in NO bioavailability, potentiation of antioxidant defense, and decrease in the expression of reactive oxygen species-forming enzymes. Regular physical exercises are considered a useful approach to treat cardiovascular diseases. Future studies should focus on detailed identification of (i) the exercise-mediated mechanisms of NO exchange; (ii) optimal exercise approaches to improve cardiovascular function in health and disease; and (iii) physical effort thresholds. | ||
| 461 | |t Frontiers in Cell and Developmental Biology | ||
| 463 | |t Vol. 2 |v [P. 73] |d 2014 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a nitric oxide | |
| 610 | 1 | |a nitric oxide synthase | |
| 610 | 1 | |a exercise | |
| 610 | 1 | |a cardiopulmonary system | |
| 610 | 1 | |a blood vessels | |
| 701 | 1 | |a Nosarev |b A. V. |c medic |c Professor of Tomsk Polytechnic University, Doctor of medical sciences |f 1977- |g Aleksey Valerievich |3 (RuTPU)RU\TPU\pers\33596 | |
| 701 | 1 | |a Smagliy |b L. V. | |
| 701 | 1 | |a Anfinogenova |b Ya. J. |c medic |c Lecturer of Tomsk Polytechnic University, Doctor of medical sciences |f 1970- |g Yana Jonovna |3 (RuTPU)RU\TPU\pers\33592 | |
| 701 | 1 | |a Popov |b S. V. | |
| 701 | 1 | |a Kapilevich |b L. V. |c specialist in the field of physical culture and sports |c Professor of Tomsk Polytechnic University, Doctor of medical sciences |f 1963- |g Leonid Vladimirovich |3 (RuTPU)RU\TPU\pers\33522 |9 17190 | |
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| 856 | 4 | |u http://dx.doi.org/10.3389%2Ffcell.2014.00073 | |
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