Preparation and Medico-Biological Tests Nanocolloids Radiopharmaceuticals on the Based of Modified DTPA Labeled Technetium-99m
| Parent link: | Proceedings of the International ConferenceNanomaterials: Applications and Properties (NAP-2013) Alushta, the Crimea, Ukraine September 16-21, 2013.— , 2013 Vol. 2, № 4.— 2013.— 04NABM02 [4 p.] |
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| Další autoři: | , , , , , |
| Shrnutí: | Title screen Technetium-99m recovery process in the presence of stannous Sn (II) with the aim to determine it is necessary and sufficient quantity, that would provide a complete "recovery" of 99mTc in the reaction mixture has been investigated. The studies were identified conditions for receiving radioactive nanopreparations based on a modified molecule DTPA. The authors has been shown that the direct interaction of 99mTc eluate solution with a solution of a mixture of SnCl2 DTPAmod and radiochemical impurity content unreduced 99mTc (VII) in the preparation labeled with nanocolloids is 2,7% and the yield nanocolloids with the size of 100 nm is about 80%. The medical-biological testing of the agents 99mTc (IV) - DTPAmod on test animals for the determination of the functional suitability for the scintigraphic imaging of lymph nodes has been carried out. |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | http://mmgp.ru.essuir.sumdu.edu.ua/bitstream/123456789/35405/1/princon_2013_2_4_26.pdf |
| Médium: | Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=637510 |
| Shrnutí: | Title screen Technetium-99m recovery process in the presence of stannous Sn (II) with the aim to determine it is necessary and sufficient quantity, that would provide a complete "recovery" of 99mTc in the reaction mixture has been investigated. The studies were identified conditions for receiving radioactive nanopreparations based on a modified molecule DTPA. The authors has been shown that the direct interaction of 99mTc eluate solution with a solution of a mixture of SnCl2 DTPAmod and radiochemical impurity content unreduced 99mTc (VII) in the preparation labeled with nanocolloids is 2,7% and the yield nanocolloids with the size of 100 nm is about 80%. The medical-biological testing of the agents 99mTc (IV) - DTPAmod on test animals for the determination of the functional suitability for the scintigraphic imaging of lymph nodes has been carried out. |
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