High detection sensitivity achieved with cryogenic detectors in combination with matrix-assisted laser desorption / ionisation time-of-flight mass spectrometry (MALDI-TOF MS); European Journal of Mass Spectrometry; Vol. 10, iss. 4
| Parent link: | European Journal of Mass Spectrometry: Scientific Journal.— , 1995- Vol. 10, iss. 4.— 2004.— [P. 469-476] |
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| Drugi avtorji: | , , , , , , |
| Izvleček: | Title screen Cryogenic detectors directly measure the impact energy of any impinging particle independent of its velocity. Thus a very high, mass-independent, detection efficiency is expected from their application in TOF-MS. The cryogenic detector applied here is based on a superconducting phase-transition thermometer and was implemented in a dual reflector time-of-flight mass spectrometer (N-geometry). A dilution series using standard sample preparation procedures shows that the detection limit for insulin (Mr: 5,734) can be decreased by several orders of magnitude, down to 0.5 amol on the MALDI target. Detection limits for rhM-CSF ß (Mr: 49,032) and for polyclonal IgG (Mr: ca. 150,000) in the high femtomole and low picomole range, respectively, were established |
| Jezik: | angleščina |
| Izdano: |
2004
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| Teme: | |
| Online dostop: | http://www.impublications.com/content/abstract?code=E10_0469 https://publications.mpp.mpg.de/?action=search&mpi=MPP-2003-141 |
| Format: | Elektronski Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=637165 |
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| 200 | 1 | |a High detection sensitivity achieved with cryogenic detectors in combination with matrix-assisted laser desorption / ionisation time-of-flight mass spectrometry (MALDI-TOF MS) |f P. Christ [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [Ref.: (23 tit.)] | ||
| 330 | |a Cryogenic detectors directly measure the impact energy of any impinging particle independent of its velocity. Thus a very high, mass-independent, detection efficiency is expected from their application in TOF-MS. The cryogenic detector applied here is based on a superconducting phase-transition thermometer and was implemented in a dual reflector time-of-flight mass spectrometer (N-geometry). A dilution series using standard sample preparation procedures shows that the detection limit for insulin (Mr: 5,734) can be decreased by several orders of magnitude, down to 0.5 amol on the MALDI target. Detection limits for rhM-CSF ß (Mr: 49,032) and for polyclonal IgG (Mr: ca. 150,000) in the high femtomole and low picomole range, respectively, were established | ||
| 461 | |t European Journal of Mass Spectrometry |o Scientific Journal |d 1995- | ||
| 463 | |t Vol. 10, iss. 4 |v [P. 469-476] |d 2004 | ||
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| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a криогенные детекторы | |
| 610 | 1 | |a cryogenic detector | |
| 610 | 1 | |a масс-спектрометрия | |
| 610 | 1 | |a MALDI | |
| 701 | 1 | |a Christ |b P. | |
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| 856 | 4 | |u http://www.impublications.com/content/abstract?code=E10_0469 | |
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