A Highly K+-Selective Phenylaza-[18]crown-6-Lariat-Ether-Based Fluoroionophore and Its Application in the Sensing of K+ Ions with an Optical Sensor Film and in Cells; Chemistry - A European Journal; Vol. 19, iss. 42

A Highly K+-Selective Phenylaza-[18]crown-6-Lariat-Ether-Based Fluoroionophore and Its Application in the Sensing of K+ Ions with an Optical Sensor Film and in Cells; Chemistry - A European Journal; Vol. 19, iss. 42

Podrobná bibliografie
Parent link:Chemistry - A European Journal
Vol. 19, iss. 42.— 2013.— [P. 8]
Korporativní autor: Национальный исследовательский Томский политехнический университет (ТПУ)
Další autoři: Ast S. Sandra, Schwarze T. Thomas, Muller H. Holger, Sukhanov A. V. Aleksey Viktorovich, Michaelis S. Stefanie, Wegener J. Joachim, Wolfbeis O. Otto, Korzdorfer T. Thomas, Durkop A. Axel, Holdt H. Hans-Jurgen
Shrnutí:Title screen
Herein, we report the synthesis of two phenylaza-[18]crown-6 lariat ethers with a coumarin fluorophore (1 and 2) and we reveal that compound 1 is an excellent probe for K+ ions under simulated physiological conditions. The presence of a 2-methoxyethoxy lariat group at the ortho position of the anilino moiety is crucial to the substantially increased stability of compounds 1 and 2 over their lariat-free phenylaza-[18]crown-6 ether analogues. Probe 1 shows a high K+/Na+ selectivity and a 2.5-fold fluorescence enhancement was observed in the presence of 100 mM K+ ions. A fluorescent membrane sensor, which was prepared by incorporating probe 1 into a hydrogel, showed a fully reversible response, a response time of 150 s, and a signal change of 7.8?% per 1 mM?K+ within the range 1–10 mM?K+. The membrane was easily fabricated (only a single sensing layer on a solid polyester support), yet no leaching was observed. Moreover, compound 1 rapidly permeated into cells, was cytocompatible, and was suitable for the fluorescent imaging of K+ ions on both the extracellular and intracellular levels.
Режим доступа: по договору с организацией-держателем ресурса
Jazyk:angličtina
Vydáno: 2013
Témata:
труды учёных ТПУ
электронный ресурс
fluorescence
флуоресценция
gels
гели
potassium
калий
sensors
датчики
On-line přístup:http://dx.doi.org/10.1002/chem.201302350
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=636158

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