Оценка противоопухолевой эффективности различных видов ИПМИ в сочетанном действии с доксорубицином in vitro; Перспективы развития фундаментальных наук; Т. 4 : Биология и фундаментальная медицина
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 24-27 апреля 2018 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2018 Т. 4 : Биология и фундаментальная медицина.— 2018.— [С. 122-124] |
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| Summary: | Заглавие с экрана It is known that the action of high-amplitude electric pulses can significantly increase the permeability of cell membranes due to the formation of pores in them (electroporation). The aim of this research was to study the possibility of forming electropores in membranes of tumor cells by means of a non-invasive method using nanosecond microwave pulses for effective delivery of chemotherapeutic agents to the cell. The HeLa cell line was used as a model object. Doxorubicin was used as a chemotherpeutic drug in various concentrations: 0.5, 1.0 and 2.5 [mu]M. Radiation was carried out on two sources of pulsed-periodic microwave radiation, characterized by different parameters. It was found that, 24 hours after exposure at pulse repetition rates of 13 and 16 Hz in combination with doxorubicin, there was an increase in inhibition of tumor cell proliferation by 30 and 40 %, respectively. |
| Sprog: | russisk |
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2018
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| Online adgang: | http://earchive.tpu.ru/handle/11683/50906 |
| Format: | MixedMaterials Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=627670 |
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| 200 | 1 | |a Оценка противоопухолевой эффективности различных видов ИПМИ в сочетанном действии с доксорубицином in vitro |d Antitumor therapy efficiency of different types of nanosecond pulseperiodic microwave radiation in combination with doxorubicin in vitro |f Е. А. Просекина |g науч. рук. М. А. Булдаков | |
| 203 | |a Текст |c электронный | ||
| 230 | |a 1 компьютерный файл (pdf; 223 Kb) | ||
| 300 | |a Заглавие с экрана | ||
| 320 | |a [Библиогр.: с. 124 (4 назв.)] | ||
| 330 | |a It is known that the action of high-amplitude electric pulses can significantly increase the permeability of cell membranes due to the formation of pores in them (electroporation). The aim of this research was to study the possibility of forming electropores in membranes of tumor cells by means of a non-invasive method using nanosecond microwave pulses for effective delivery of chemotherapeutic agents to the cell. The HeLa cell line was used as a model object. Doxorubicin was used as a chemotherpeutic drug in various concentrations: 0.5, 1.0 and 2.5 [mu]M. Radiation was carried out on two sources of pulsed-periodic microwave radiation, characterized by different parameters. It was found that, 24 hours after exposure at pulse repetition rates of 13 and 16 Hz in combination with doxorubicin, there was an increase in inhibition of tumor cell proliferation by 30 and 40 %, respectively. | ||
| 461 | 1 | |0 (RuTPU)RU\TPU\conf\26928 |t Перспективы развития фундаментальных наук |l Prospects of Fundamental Sciences Development |o сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 24-27 апреля 2018 г. |o в 7 т. |f Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой |d 2018 | |
| 463 | 1 | |0 (RuTPU)RU\TPU\conf\26932 |t Т. 4 : Биология и фундаментальная медицина |v [С. 122-124] |d 2018 | |
| 510 | 1 | |a Antitumor therapy efficiency of different types of nanosecond pulseperiodic microwave radiation in combination with doxorubicin in vitro |z eng | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a противоопухолевая терапия | |
| 610 | 1 | |a эффективность | |
| 610 | 1 | |a устойчивость | |
| 610 | 1 | |a опухолевые клетки | |
| 610 | 1 | |a электрические импульсы | |
| 610 | 1 | |a лекарственное обеспечение | |
| 610 | 1 | |a лучевая терапия | |
| 700 | 1 | |a Просекина |b Е. А. | |
| 702 | 1 | |a Булдаков |b М. А. |4 727 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский государственный университет (ТГУ) |c (2009- ) |2 stltpush |3 (RuTPU)RU\TPU\col\17230 |
| 801 | 2 | |a RU |b 63413507 |c 20181008 |g RCR | |
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/50906 | |
| 942 | |c BK | ||