Молекулярные мишени гиполипидемического действия сесквитерпеновых лактонов
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 24-27 апреля 2018 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2018 Т. 4 : Биология и фундаментальная медицина.— 2018.— [С. 69-71] |
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| Zusammenfassung: | Заглавие с экрана Experiments on rats with hyperlipidemia model induced by cholesterol-rich diet during 4 weeks showed that the daily treatment with sesquiterpene lactone grossgemin and ludartin in doses 10 mg/kg for a period of 14 days led to decrease hypertriglyceridemia, fat acids, common cholesterol and low density lipoproteins cholesterol serum content. Grossgemin and ludartin in the liver increase the expression of mRNA genes that code acyl-Co A: cholesterol acyltransferase, cholesterol-7[alpha]-hydroxylase, carnitin-palmytoiltransferases 1 and 2. Grossgemin increase the expression of mRNA gene3-hydroxy-3-methylglutaryl-Co A reductase. |
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2018
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| Online-Zugang: | http://earchive.tpu.ru/handle/11683/50887 |
| Format: | Elektronisch Buchkapitel |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=627652 |
| Zusammenfassung: | Заглавие с экрана Experiments on rats with hyperlipidemia model induced by cholesterol-rich diet during 4 weeks showed that the daily treatment with sesquiterpene lactone grossgemin and ludartin in doses 10 mg/kg for a period of 14 days led to decrease hypertriglyceridemia, fat acids, common cholesterol and low density lipoproteins cholesterol serum content. Grossgemin and ludartin in the liver increase the expression of mRNA genes that code acyl-Co A: cholesterol acyltransferase, cholesterol-7[alpha]-hydroxylase, carnitin-palmytoiltransferases 1 and 2. Grossgemin increase the expression of mRNA gene3-hydroxy-3-methylglutaryl-Co A reductase. |
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