Молекулярное моделирование биологически активных соединений лигандов для ГАМКА рецепторов
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 24-27 апреля 2018 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2018 Т. 4 : Биология и фундаментальная медицина.— 2018.— [С. 57-59] |
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| Awduron Corfforaethol: | , |
| Awduron Eraill: | , |
| Crynodeb: | Заглавие с экрана GABAA receptor mediates inhibitory neurotransmission in the central nervous system. A lot of compounds modulating GABAAreceptor and, thus, having anxiolytic or sedative effect has been developed. Herein the analysis of interaction between GABAAreceptor, in particular, its benzodiazepine site,and a set of new ligands consisting of ureas, their benzhydryl derivatives and barbituric acidderivatives studied by molecular docking is presented.It was demonstrated that among investigated 49 compounds, B-100 (S) has the highest binding affinity to the benzodiazepine site. |
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2018
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| Mynediad Ar-lein: | http://earchive.tpu.ru/handle/11683/50881 |
| Fformat: | Electronig Pennod Llyfr |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=627648 |
| Crynodeb: | Заглавие с экрана GABAA receptor mediates inhibitory neurotransmission in the central nervous system. A lot of compounds modulating GABAAreceptor and, thus, having anxiolytic or sedative effect has been developed. Herein the analysis of interaction between GABAAreceptor, in particular, its benzodiazepine site,and a set of new ligands consisting of ureas, their benzhydryl derivatives and barbituric acidderivatives studied by molecular docking is presented.It was demonstrated that among investigated 49 compounds, B-100 (S) has the highest binding affinity to the benzodiazepine site. |
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