Исследование деградации парацетамола в 2M растворах фосфатно-солевого буфера
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 24-27 апреля 2018 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2018 Т. 2 : Химия.— 2018.— [С. 267-269] |
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| Autore principale: | |
| Ente Autore: | |
| Altri autori: | , , , |
| Riassunto: | Заглавие с экрана Developing new drug delivery systems requires carrying out a solubility test, mainly in neutral pH range, to study drug release. However, there is a problem of degradation of the active substance during the test, which makes it difficult to assess the dynamics of release from the carrier. In this paper, the dynamics of the paracetamol degradation in various concentration's phosphate buffer saline solutions was evaluated by liquid UV-vis spectroscopy. It is shown, that after two weeks paracetomol concentration decreases no less than up to 50 wt.% and the degradation rate depends on the solution concentration. |
| Lingua: | russo |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | http://earchive.tpu.ru/handle/11683/50789 |
| Natura: | Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=627563 |
| Riassunto: | Заглавие с экрана Developing new drug delivery systems requires carrying out a solubility test, mainly in neutral pH range, to study drug release. However, there is a problem of degradation of the active substance during the test, which makes it difficult to assess the dynamics of release from the carrier. In this paper, the dynamics of the paracetamol degradation in various concentration's phosphate buffer saline solutions was evaluated by liquid UV-vis spectroscopy. It is shown, that after two weeks paracetomol concentration decreases no less than up to 50 wt.% and the degradation rate depends on the solution concentration. |
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