Широкогеномное иссл едование прогностической значимости явления потери гетерозиготности в опухолевой ткани молочной железы; Перспективы развития фундаментальных наук; Т. 4 : Биология и фундаментальная медицина
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2017 Т. 4 : Биология и фундаментальная медицина.— 2017.— [С. 175-177] |
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| Autore principale: | |
| Altri autori: | , , |
| Riassunto: | Заглавие с экрана One of the variability factors of malignant tumors, particularly breast cancer is a genetic variation due to gene polymorphism, and especially - the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. Thus, the aim of this work was genome-wide association study of loss of heterozygosity and Metastasis-free survival in breast cancer. The study involved 68 patients with breast cancer. To evaluate LOH status that was conducted by microarray analysis on high density DNA-chips made by firm Affymetrix CytoScanTM HD Array. 13 815 genes were evaluated in order to reveal loss of heterozygosity. The frequency of LOH varied from 0% to 63%. As a result of the associative analysis four genes EDA2R, PGK1, TAF9B and CYSLTR1 were determined, the presence of loss of heterozygosity that was associated with Metastasis-free survival. The presence of LOH in these genes is associated with low Metastasisfree survival. |
| Lingua: | russo |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | http://earchive.tpu.ru/handle/11683/44892 |
| Natura: | Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=625103 |
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| 200 | 1 | |a Широкогеномное иссл едование прогностической значимости явления потери гетерозиготности в опухолевой ткани молочной железы |d Genomic approach in the research prognostic significance of effects loss of heterozygosity in tumor tissue breast |f М. М. Цыганов, И. В. Дерюшева, М. К. Ибрагимова |g науч. рук. Н. В. Литвяков | |
| 203 | |a Текст |c электронный | ||
| 230 | |a 1 компьютерный файл (pdf; 458 Kb) | ||
| 300 | |a Заглавие с экрана | ||
| 320 | |a [Библиогр.: с. 177 (2 назв.)] | ||
| 330 | |a One of the variability factors of malignant tumors, particularly breast cancer is a genetic variation due to gene polymorphism, and especially - the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. Thus, the aim of this work was genome-wide association study of loss of heterozygosity and Metastasis-free survival in breast cancer. The study involved 68 patients with breast cancer. To evaluate LOH status that was conducted by microarray analysis on high density DNA-chips made by firm Affymetrix CytoScanTM HD Array. 13 815 genes were evaluated in order to reveal loss of heterozygosity. The frequency of LOH varied from 0% to 63%. As a result of the associative analysis four genes EDA2R, PGK1, TAF9B and CYSLTR1 were determined, the presence of loss of heterozygosity that was associated with Metastasis-free survival. The presence of LOH in these genes is associated with low Metastasisfree survival. | ||
| 461 | 1 | |0 (RuTPU)RU\TPU\conf\21388 |t Перспективы развития фундаментальных наук |l Prospects of Fundamental Sciences Development |o сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г. |o в 7 т. |f Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой |d 2017 | |
| 463 | 1 | |0 (RuTPU)RU\TPU\conf\21393 |t Т. 4 : Биология и фундаментальная медицина |v [С. 175-177] |d 2017 | |
| 510 | 1 | |a Genomic approach in the research prognostic significance of effects loss of heterozygosity in tumor tissue breast |z eng | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a полиморфизм | |
| 610 | 1 | |a генотип | |
| 610 | 1 | |a ДНК | |
| 610 | 1 | |a молочные железы | |
| 610 | 1 | |a онкология | |
| 610 | 1 | |a опухоли | |
| 700 | 1 | |a Цыганов |b М. М. | |
| 701 | 1 | |a Дерюшева |b И. В. | |
| 701 | 1 | |a Ибрагимова |b М. К. | |
| 702 | 1 | |a Литвяков |b Н. В. |4 727 | |
| 801 | 2 | |a RU |b 63413507 |c 20171211 |g RCR | |
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/44892 | |
| 942 | |c BK | ||