Широкогеномное иссл едование прогностической значимости явления потери гетерозиготности в опухолевой ткани молочной железы
| Parent link: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2017 Т. 4 : Биология и фундаментальная медицина.— 2017.— [С. 175-177] |
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| Інші автори: | , , |
| Резюме: | Заглавие с экрана One of the variability factors of malignant tumors, particularly breast cancer is a genetic variation due to gene polymorphism, and especially - the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. Thus, the aim of this work was genome-wide association study of loss of heterozygosity and Metastasis-free survival in breast cancer. The study involved 68 patients with breast cancer. To evaluate LOH status that was conducted by microarray analysis on high density DNA-chips made by firm Affymetrix CytoScanTM HD Array. 13 815 genes were evaluated in order to reveal loss of heterozygosity. The frequency of LOH varied from 0% to 63%. As a result of the associative analysis four genes EDA2R, PGK1, TAF9B and CYSLTR1 were determined, the presence of loss of heterozygosity that was associated with Metastasis-free survival. The presence of LOH in these genes is associated with low Metastasisfree survival. |
| Опубліковано: |
2017
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| Предмети: | |
| Онлайн доступ: | http://earchive.tpu.ru/handle/11683/44892 |
| Формат: | Електронний ресурс Частина з книги |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=625103 |
| Резюме: | Заглавие с экрана One of the variability factors of malignant tumors, particularly breast cancer is a genetic variation due to gene polymorphism, and especially - the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. Thus, the aim of this work was genome-wide association study of loss of heterozygosity and Metastasis-free survival in breast cancer. The study involved 68 patients with breast cancer. To evaluate LOH status that was conducted by microarray analysis on high density DNA-chips made by firm Affymetrix CytoScanTM HD Array. 13 815 genes were evaluated in order to reveal loss of heterozygosity. The frequency of LOH varied from 0% to 63%. As a result of the associative analysis four genes EDA2R, PGK1, TAF9B and CYSLTR1 were determined, the presence of loss of heterozygosity that was associated with Metastasis-free survival. The presence of LOH in these genes is associated with low Metastasisfree survival. |
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