Анеуплоидия в цито трофобласте эмбрионов человека с различным глобальным уровнем метилирования генома; Перспективы развития фундаментальных наук; Т. 4 : Биология и фундаментальная медицина
| Источник: | Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2017 Т. 4 : Биология и фундаментальная медицина.— 2017.— [С. 145-147] |
|---|---|
| Главный автор: | |
| Другие авторы: | |
| Примечания: | Заглавие с экрана In this study, we investigated the frequency of aneuploidy of chromosomes 8 and X in human embryonic tissues with different level of global genome methylation. A comparative analysis of the methylation index of LINE-1 retrotransposon, which is largely reflecting the methylation profile of the genome, is performed in cytotrophoblast cells of 24 spontaneous abortions with a normal karyotype, as well as in the control group of 17 induced abortions of the first trimester of pregnancy. It was shown that the cytotrophoblast of spontaneous abortions with normal karyotype and with hypomethylation of LINE-1 is characterized by increased frequency of aneuploidy of chromosome 8, however, the frequency of aneuploidy of X chromosome was not differed significantly between the explored groups of abortions. In addition, it should be noted, that the high frequency of aneuploidy in the cytotrophoblast cells of abortions was much higher than it was detected in other tissues of the human organism. |
| Язык: | русский |
| Опубликовано: |
2017
|
| Предметы: | |
| Online-ссылка: | http://earchive.tpu.ru/handle/11683/44881 |
| Формат: | Электронный ресурс Статья |
| Запись в KOHA: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=625082 |
MARC
| LEADER | 00000naa2a2200000 4500 | ||
|---|---|---|---|
| 001 | 625082 | ||
| 005 | 20231101133338.0 | ||
| 035 | |a (RuTPU)RU\TPU\conf\24342 | ||
| 035 | |a RU\TPU\conf\24340 | ||
| 090 | |a 625082 | ||
| 100 | |a 20171206d2017 k y0rusy50 ca | ||
| 101 | 0 | |a rus |d eng | |
| 102 | |a RU | ||
| 105 | |a y z 100zy | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Анеуплоидия в цито трофобласте эмбрионов человека с различным глобальным уровнем метилирования генома |d Aneuploidy in human embryonic cytotrophoblast with different level of global genome methylation |f Р. Р. Савченко, С. А. Васильев |g науч. рук. С. А. Васильев | |
| 203 | |a Текст |c электронный | ||
| 230 | |a 1 компьютерный файл (pdf; 172 Kb) | ||
| 300 | |a Заглавие с экрана | ||
| 320 | |a [Библиогр.: с. 147 (3 назв.)] | ||
| 330 | |a In this study, we investigated the frequency of aneuploidy of chromosomes 8 and X in human embryonic tissues with different level of global genome methylation. A comparative analysis of the methylation index of LINE-1 retrotransposon, which is largely reflecting the methylation profile of the genome, is performed in cytotrophoblast cells of 24 spontaneous abortions with a normal karyotype, as well as in the control group of 17 induced abortions of the first trimester of pregnancy. It was shown that the cytotrophoblast of spontaneous abortions with normal karyotype and with hypomethylation of LINE-1 is characterized by increased frequency of aneuploidy of chromosome 8, however, the frequency of aneuploidy of X chromosome was not differed significantly between the explored groups of abortions. In addition, it should be noted, that the high frequency of aneuploidy in the cytotrophoblast cells of abortions was much higher than it was detected in other tissues of the human organism. | ||
| 461 | 1 | |0 (RuTPU)RU\TPU\conf\21388 |t Перспективы развития фундаментальных наук |l Prospects of Fundamental Sciences Development |o сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г. |o в 7 т. |f Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой |d 2017 | |
| 463 | 1 | |0 (RuTPU)RU\TPU\conf\21393 |t Т. 4 : Биология и фундаментальная медицина |v [С. 145-147] |d 2017 | |
| 510 | 1 | |a Aneuploidy in human embryonic cytotrophoblast with different level of global genome methylation |z eng | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a кариотип | |
| 610 | 1 | |a сегрегация | |
| 610 | 1 | |a хромосомы | |
| 610 | 1 | |a геномы | |
| 610 | 1 | |a эпигенетические процессы | |
| 700 | 1 | |a Савченко |b Р. Р. | |
| 701 | 1 | |a Васильев |b С. А. | |
| 702 | 1 | |a Васильев |b С. А. |4 727 | |
| 801 | 2 | |a RU |b 63413507 |c 20171211 |g RCR | |
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/44881 | |
| 942 | |c BK | ||