Динамика снижения содержания миелина после моделирования локальной ишемии головного мозга у крыс

Динамика снижения содержания миелина после моделирования локальной ишемии головного мозга у крыс

Bibliographic Details
Parent link:Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г./ Национальный исследовательский Томский политехнический университет (ТПУ) ; под ред. И. А. Курзиной, Г. А. Вороновой.— , 2017
Т. 4 : Биология и фундаментальная медицина.— 2017.— [С. 76-78]
Main Author: Кисель А. А.
Other Authors: Ходанович М. Ю. (727)
Summary:Заглавие с экрана
A majority of studies were usually focused on neuronal death after brain ischemia, however, stroke affects all cell types including oligodendrocytes that form myelin sheath in the CNS. Our study is focused on the changes of myelin content in ischemic core and neighbor structures in early terms (1, 3 and 10 days) after stroke. Stroke modeled with middle cerebral artery occlusion (MCAo) in 15 male rats that were divided in three groups by time-points after operation. Brain sections were histologically stained with Luxol Fast Blue (LFB) for myelin quantification. The significant demyelination was found in the ischemic core, corpus callosum, anterior commissure, whereas myelin content was increased in caudoputamen, internal capsule and piriform cortex compared with the contralateral hemisphere. The motor cortex showed a significant increase of myelin content on the 1st day and a significant decrease on the 3rd and 10th days after MCAo. These results suggest stroke influences myelination not only in ischemic core but also in distant structures.
Language:Russian
Published: 2017
Subjects:
электронный ресурс
сосудистые заболевания
ишемическая болезнь
нейроны
исследования
гистологический анализ
Online Access:http://earchive.tpu.ru/handle/11683/44857
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=625005

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